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Interactions between environmental factors and predisposing genes could be involved in the development of coeliac disease (CD). This study has assessed whether milk-feeding type and HLA-genotype influence the intestinal microbiota composition of infants with a family history of CD. The study included 164 healthy newborns, with at least one first-degree(More)
BACKGROUND Questionnaires are feasible instruments to assess physical activity (PA) in large samples. The aim of the current study was to evaluate the reliability and validity of the PAQ-A questionnaire in Spanish adolescents using the measurement of PA by accelerometer as criterion. METHODS In a sample of 82 adolescents, aged 12 to 17 years, 1-week PAQ-A(More)
Coeliac disease (CD) development involves genetic (HLA-DQ2/DQ8) and environmental factors. Herein, the influence of the HLA-DQ genotype on the gut colonization process of breast-fed children was determined. A cohort of 20 newborns, with at least one first-degree relative with CD, were classified according to their HLA-DQ genotype into high, intermediate and(More)
An 80-year-old man with a 7 year history of a slowly enlarging, asymptomatic scrotal nodule is presented. He had a negative history for sexually transmitted disease, trauma to the area, radiotherapy and chemical or arsenic exposure. The lesion was excised with a margin of 0.8 cm of normal skin. Examination of the specimen revealed a basal cell carcinoma.
During the last few decades, scientific evidence has confirmed a wide range of health benefits related to regular physical activity. How physical activity affects the immune function and infection risk is, however, still under debate. Commonly, intensive exercise suppresses the activity and levels of several immune cells, while other immune functions may be(More)
Celiac disease (CD) is an immune-mediated enteropathy involving genetic and environmental factors whose interaction might influence disease risk. The aim of this study was to determine the effects of milk-feeding practices and the HLA-DQ genotype on intestinal colonization of Bacteroides species in infants at risk of CD development. This study included 75(More)
Celiac disease is an inflammatory disorder of the small intestine, triggered by the ingestion of gluten proteins contained in wheat, barley or rye, in genetically susceptible individuals. This disorder is considered to be mainly mediated by cellular immunity and restricted to the human leucocyte antigen-DQ presentation of gluten-derived toxic peptides to(More)
HIV-associated pityriasis rubra pilaris (PRP) or PRP type VI designates a new distinctive entity reported in HIV patients. It is characterized by cutaneous lesions of PRP and variable association with lesions of acne conglobata, hidradenitis suppurativa and lichen spinulosus. We report a patient with HIV-associated PRP which was treated by triple(More)
was calculated. Considering a switch to aztreonam lysine, the reduction of exacerbation was estimated in order to maintain the overall treatment cost. For the base case, ex-factory prices were considered; for sensitivity analysis, discounts ranged from 15 to 50%. Results: Switching to aztreonam lysine would not increase overall treatment costs in 8/12(More)
Acne conglobata is a severe form of nodulocystic acne that often represents a therapeutic challenge for dermatologists due to its resistance to the usual therapies. The condition is chronic and disfiguring and has a significant impact on the patient’s quality of life. It presents with numerous comedones, papules, pustules, nodules, and abscesses on the(More)
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