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PURPOSE Computerized provider order entry (CPOE) is central to current efforts at improving clinical care. Understanding the quality of the evidence for CPOE is important to the practical decision of implementation, patient safety and future design efforts. This paper presents the results of a systematic analysis of the quality of systematic reviews of(More)
BACKGROUND & AIMS The functional involvement of the endocannabinoid system in modulation of pancreatic inflammation, such as acute pancreatitis, has not been studied to date. Moreover, the therapeutic potential of cannabinoids in pancreatitis has not been addressed. METHODS We quantified endocannabinoid levels and expression of cannabinoid receptors 1 and(More)
The use of genetically engineered mice has provided insights into the molecular pathogenesis of the pediatric brain tumor medulloblastoma and revealed promising therapeutic targets. Ectopic expression of Sonic hedgehog (Shh) in cerebellar neural progenitor cells induces medulloblastomas in mice, and coexpression of hepatocyte growth factor (HGF) enhances(More)
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