Tamara L. Chapman

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Biochemical characterization has established the presence of two conformational forms of myotoxin a. To test the hypothesis that this may be due to cis-trans isomerization at Pro20, synthetic versions of myotoxin a and its Pro20-->Gly structural homolog were folded, then purified using a two-step cation-exchange/reverse-phase perfusion chromatography(More)
The stereochemical course of the argininosuccinate synthetase reaction has been determined. The SP isomer of [alpha-17O,alpha-18O,alpha beta-18O]ATP is cleaved to (SP)-[16O,17O,18O]AMP by the action of argininosuccinate synthetase in the presence of citrulline and aspartate. The overall stereochemical transformation is therefore net inversion, and thus the(More)
The stereochemical course of the argininosuccinate synthetase reaction has been determined. The Sp isomer of [,-170,~-180,crB-180]ATP is cleaved to (Sp)-[160,170,180]AMP by the action of argininosuccinate synthetase in the presence of citrulline and aspartate. The overall stereochemical transformation is therefore net inversion, and thus the enzyme does not(More)
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