Tamara D. James

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We describe an ongoing collaboration that developed as academic investigators responded to a specific request from community members to document health effects on black women of employment in poultry-processing plants in rural North Carolina. Primary outcomes of interest are upper extremity musculoskeletal disorders and function as well as quality of life.(More)
Cystic fibrosis is one of the most commonly tested autosomal recessive disorders in the United States. Clinical cystic fibrosis is associated with mutations in the CFTR gene, of which the most common mutation among Caucasians, DeltaF508, was identified in 1989. The University of Michigan, Johns Hopkins University, and the Hospital for Sick Children, where(More)
BACKGROUND Workers in the health care industry may be exposed to a variety of work-related stressors including infectious, chemical, and physical agents; ergonomic hazards; psychological hazards; and workplace violence. Many of these hazards lack surveillance systems to evaluate exposures and health outcomes. The development and implementation of a(More)
Bordetella pertussis causes whooping cough, an infectious disease that is reemerging despite widespread vaccination. A more complete understanding of B. pertussis pathogenic mechanisms will involve unravelling the regulation of its impressive arsenal of virulence factors. Here we review the action of the B. pertussis response regulator BvgA in the context(More)
In recent years, manufacturers have produced new microscopes with claims of “ergonomic design” for reduced musculoskeletal stress among users. To test this claim, we measured posture of the neck, back, and upper extremities, and the prevalence of musculoskeletal and visual symptoms among cytotechnologists while using traditional microscopes (baseline) and(More)
  • T James
  • South African medical journal = Suid-Afrikaanse…
  • 1982
Although dacryohaemorrhoea appears in Dorland's Illustrated Medical Dictionary the word has not been found in the medical literature, but several cases of 'bloody tears' of diverse and unknown aetiology have appeared in ophthalmological journals. Prominent textbooks on ophthalmology, however, do not mention the condition. An instance of the phenomenon(More)
During infection of Escherichia coli, bacteriophage T4 usurps the host transcriptional machinery, redirecting it to the expression of early, middle, and late phage genes. Middle genes, whose expression begins about 1 min postinfection, are transcribed both from the extension of early RNA into middle genes and by the activation of T4 middle promoters.(More)
Gene expression can be regulated through factors that direct RNA polymerase to the correct promoter sequence at the correct time. Bacteriophage T4 controls its development in this way using phage proteins that interact with host RNA polymerase. Using a process called σ appropriation, the T4 co-activator AsiA structurally remodels the σ(70) subunit of host(More)