Tamar V Sanikidze

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BACKGROUND Study aimed at investigation of pathogenic role and prognostic value of several selected cerebrospinal fluid acute phase factors that can reflect the severity of ischemic brain damage. METHODS Ninety five acute ischemic stroke patients were investigated. Ischemic region visualized at the twenty fourth hour by conventional Magnetic Resonance(More)
Present research aimed at investigation of the role of several inflammatory cytokines and free toxic radicals in Multiple Sclerosis (MS) course and disability progression as well as factors that can assist to the early transition of Relapse Remitting MS (RRMS) in Secondary Progressive MS (SPMS). Totally 22 MS patients, 14 RRMS and 8 SMPS have been(More)
The skin is constantly exposed to oxidative stress induced by reactive oxygen species (ROS) that are generated both from endogenous neutrophils and external pro-oxidant stimuli. The present study was planned to investigate the possible involvement of free radical oxidation in psoriatic patients. Study was carried out in the Department of Dermatology and(More)
The aim of our study was to evaluate whether this polymorphism of CCR6 gene and oxidative stress are associated with psoriasis risk in Caucasian population. The association of the CCR6 polymorphism in the genetic susceptibility of psoriasis was performed at the Department of Dermatology and Venereology, Policlinico Umberto I of Rome (Italy). 516(More)
The case study purpose was to investigate the oxidation-antioxidation process in the affected organism after traumatic shock and under the impact of Plapherone LB. A randomized experiment involved 94 patients who were shared between 2 groups: group 1--routine intensive therapy, group 2--it received additionally Plapherone LB (sublingually, 2 mg(More)
The oxidative stress-induced changes and feasibility of prevention of these changes with an aid of vitamines E and C were investigated in cultured brain cortex of the newborn albino rats. Modeling the oxidative stress was achieved with addition of H(2)O(2) into the nutrient medium. In order to prevent an oxidative stress-induced cytotoxic effect,(More)
Lead is a ubiquitous environmental toxin that is capable of causing numerous acute and chronic circulatory, neurological, hematological, gastrointestinal, reproductive and immunological pathologies. The mechanism of lead induced toxicity is not fully understood. The prime targets to lead toxicity are the heme synthesis enzymes, thiol-containing antioxidants(More)
Axon degeneration accompanying its demielinization is a main course of neurological insufficiency typical for GBS. The mechanisms of axon degeneration, considered as the secondary result of serve inflammation are not established. We aimed to determine the role of oxidative metabolism in viral polyneuropathy pathogenesis. The activity of pro- and antioxidant(More)
Atherosclerotic disease remains a major cause of death. Documented cases of atherosclerosis in Georgia (Caucasus) have increased by up to 40% and, moreover, the disease is occurring with increased frequency and greater severity in younger adults. Prevention of atherosclerosis as well as detection at early stages of the disease is reviewed. The authors argue(More)
The aim of our study was to investigate age related changes of physical-chemical parameters of erythrocytes. It is known that insufficiency of erythrocytes antioxidant defence system in newborns is a keystone of peculiarities manifested in homeostasis among this group. The excess volume of reactive oxygen determines disorders related to the functioning of(More)