Tam Le Nhan

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Reversible and localized blood-brain barrier disruption (BBBD) using focused ultrasound (FUS) in combination with intravascularly administered microbubbles (MBs) has been established as a non-invasive method for drug delivery to the brain. Using two-photon fluorescence microscopy (2 PFM), we imaged the cerebral vasculature during BBBD and observed the(More)
Doxorubicin (Dox) is a well-established chemotherapeutic agent, however it has limited efficacy in treating brain malignancies due to the presence of the blood-brain barrier (BBB). Recent preclinical studies have demonstrated that focused ultrasound induced BBB disruption (BBBD) enables efficient delivery of Dox to the brain. For future treatment planning(More)
We evaluated the performance of the automated body fluid mode of the Sysmex XE-5000 series automated haematology analyzer and compared the performance of the automated method for obtaining white blood cell (WBC), red blood cell (RBC) counts and WBC differential counts with microscopic method. One hundred and seventy-four samples were analysed: 81 ascitic(More)
Transcranial focused ultrasound (FUS) can cause temporary, localized increases in blood-brain barrier (BBB) permeability for effective drug delivery to the brain. In pre-clinical models of Alzheimer's disease, FUS has successfully been used to deliver therapeutic agents and endogenous therapeutic molecules to the brain leading to plaque reduction and(More)
Virtual Machine Image (VMI) provisioning is an important process of Infrastructure as a Service delivery model to provide virtual images in Cloud Computing. The power consumption and energy efficiency of VMI provisioning process depend not only on the hardware infrastructure, but also on the VMI\,'s configuration, which helps to compose, configure and(More)
Focused ultrasound (FUS) and microbubbles have been used effectively for transient, noninvasive blood¿ brain barrier disruption (BBBD). The use of two-photon microscopy (2PM) imaging of BBBD can provide valuable insights into the associated cellular mechanisms and fundamental biological effects. Coupling a thin ring-shaped transducer to a coverslip offers a(More)
Acknowledgments First of all, I would like to sincerely thank to my advisors, Prof. Jean-Marc Jézéquel and Dr. Gerson Sunyé for guiding and supporting me at every step throughout my Ph.D, for everything I learned about research from them. I specially thank Prof. Jean-Marc Jézéquel for giving me the opportunity to come to France for doing my Ph.D in INRIA,(More)
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