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OBJECTIVE Measurement of the immunoreactive urinary albumin (ir-uAlb) concentration by immunological methods was found to be an effective method to identify disease activity in Crohn's disease (CD). Recently a size-exclusion (SE) high performance liquid chromatography (HPLC) method was developed to measure both ir-uAlb and non-immunoreactive urinary albumin(More)
To compare intrathoracic blood volume (ITBV) guided fluid management and central venous pressure (CVP) guided therapy in ameliorating the progression of early systemic inflammatory response in patients undergoing major surgery. Prospective, randomized clinical trial. Forty patients undergoing major abdominal surgery were randomized into CVP and ITBV groups.(More)
OBJECTIVE To determine whether migraineurs may have a systemic deficiency of magnesium. BACKGROUND Magnesium deficiency has been shown to play a potential role in the pathogenesis of migraine, but there are no data on total body magnesium status in migraineurs. METHODS An oral magnesium load test was performed by giving 3000 mg of magnesium lactate(More)
Fluorescence polarization (P) and anisotropy (rs) of the diphenyl-hexatriene labeled, stimulated human lymphocytes were followed in relation to cell cycle progression. Fluorescence anisotropy is proportional to the structural order parameter of the apolar lipid region, thus, indicative of the membrane fluidity. Cell cycle progression was defined by(More)
Objective. Our objective was to investigate whether short-term infusion of the oxygen free radical scavenger N-acetylcysteine (NAC) administered before and during extensive abdominal surgery could ameliorate the progression of early systemic inflammatory response. Design. Prospective, randomised, double-blinded, placebo-controlled clinical trial. Setting.(More)
The aim of this study was to present morphological and functional evidence to evaluate whether tear secretion is influenced by neuropeptides released from sensory nerve endings of the conjunctiva. Following unilateral electrical stimulation of the trigeminal ganglion, tears were collected at both sides and assessed for volume and protein concentration; as(More)
INTRODUCTION Experimental studies have demonstrated that dextran-70 reduces the leukocyte-endothelium interaction, but clinical evidence is still lacking. Our objective was to justify the anti-inflammatory effect of dextran-70 following cardiac operations. METHODS Forty patients undergoing coronary bypass surgery (n = 32) or aortic valve replacement (n =(More)
Protoapigenone (Pa) is a flavone aglycone with a p-quinol structure in its B-ring. It was first discovered in Thelypteris torresiana, a native fern in Taiwan. Recent studies highlighted that protoapigenone and some of its derivatives show very potent anticancer activity against several types of tumors, using both in vitro and in vivo models. Despite the(More)
Antioxidant activities of three selected Micromeria species growing in Croatia (M. croatica, M. juliana and M. thymifolia) were evaluated using five different antioxidant assays, in comparison with plant polyphenolic constituents and reference antioxidants. All studied ethanolic extracts exhibited considerable activity to scavenge DPPH and hydroxyl free(More)
BACKGROUND/AIMS Erythropoietin-resistance is an unsolved concern in the treatment of renal anaemia. We aimed to investigate the possible role of ortho- and meta-tyrosine - the hydroxyl free radical products of L-phenylalanine - in the development of erythropoietin-resistance. METHODS TF-1 erythroblast cell line was used. Cell concentration was determined(More)