• Publications
  • Influence
Site-Specific Pseudouridine Formation in Preribosomal RNA Is Guided by Small Nucleolar RNAs
During the nucleolar maturation of eukaryotic ribosomal RNAs, many selected uridines are converted into pseudouridine by a thus far undefined mechanism. The nucleolus contains a large number of smallExpand
  • 553
  • 34
The family of box ACA small nucleolar RNAs is defined by an evolutionarily conserved secondary structure and ubiquitous sequence elements essential for RNA accumulation.
Eukaryotic cells contain a large number of small nucleolar RNAs (snoRNAs). A major family of snoRNAs features a consensus ACA motif positioned 3 nucleotides from the 3' end of the RNA. In this studyExpand
  • 316
  • 33
Site-Specific Ribose Methylation of Preribosomal RNA: A Novel Function for Small Nucleolar RNAs
Eukaryotic cells contain many fibrillarin-associated small nucleolar RNAs (snoRNAs) that possess long complementarities to mature rRNAs. Characterization of 21 novel antisense snoRNAs from humanExpand
  • 735
  • 30
Small Nucleolar RNAs An Abundant Group of Noncoding RNAs with Diverse Cellular Functions
Small nucleolar RNAs represent an abundant, evolutionarily ancient group of noncoding RNAs which possess impressively diverse functions ranging from 2'-O-methylation and pseudouridylation of variousExpand
  • 698
  • 27
U17/snR30 Is a Ubiquitous snoRNA with Two Conserved Sequence Motifs Essential for 18S rRNA Production
ABSTRACT Saccharomyces cerevisiae snR30 is an essential box H/ACA small nucleolar RNA (snoRNA) required for the processing of 18S rRNA. Here, we show that the previously characterized human,Expand
  • 92
  • 11
7‐2/MRP RNAs in plant and mammalian cells: association with higher order structures in the nucleolus.
Mammalian MRP (for mitochondrial RNA processing) RNA, also known as 7‐2 RNA, is a nuclear encoded small RNA which has been reported to function in two different cellular compartments: in theExpand
  • 91
  • 7
Exonucleolytic processing of small nucleolar RNAs from pre-mRNA introns.
Many small nucleolar RNAs (snoRNAs) in vertebrates are encoded within introns of protein genes. We have reported previously that two isoforms of human U17 snoRNA are encoded in introns of theExpand
  • 154
  • 5
Human intron-encoded Alu RNAs are processed and packaged into Wdr79-associated nucleoplasmic box H/ACA RNPs.
Alu repetitive sequences are the most abundant short interspersed DNA elements in the human genome. Full-length Alu elements are composed of two tandem sequence monomers, the left and right Alu arms,Expand
  • 39
  • 5
Small nucleolar RNAs encoded by introns of the human cell cycle regulatory gene RCC1.
Eukaryotic cells contain a large number of U small nuclear RNAs (U‐snRNAs) involved in various RNA processing reactions in the nucleoplasm and nucleous. Most of the U‐snRNAs have 5′‐terminal capsExpand
  • 96
  • 4
Processing of Intron-Encoded Box C/D Small Nucleolar RNAs Lacking a 5′,3′-Terminal Stem Structure
ABSTRACT The C and D box-containing (box C/D) small nucleolar RNAs (snoRNAs) function in the nucleolytic processing and 2′-O-methylation of precursor rRNA. In vertebrates, most box C/D snoRNAs areExpand
  • 41
  • 4