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Accumulating evidence suggests that regulatory T cells play a crucial role in preventing autoimmunity. Recently, a naturally occurring CD4+CD25+ T-cell subset that is anergic and also suppressive has been shown to suppress autoimmunity in several animal models. We used proteoglycan-induced arthritis (PGIA) as a study model to investigate the role of the(More)
BACKGROUND The aim of the study was to examine the reactivity of peripheral human leukocytes to various metal ions prior and following hip replacement in order to investigate implant-induced metal sensitivity. METHODS Three patient groups were set up: (1) individuals without implants and no history of metal allergy (7 cases), (2) individuals without(More)
BACKGROUND Focal cartilage lesions in the knee joint have limited capacity to heal. Current animal experiments show that incisions of the deep zone of a cartilage allograft allow acceptable integration for the graft. QUESTIONS/PURPOSES We performed this clinical study to determine (1) if the multiply incised cartilage graft is surgically applicable for(More)
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