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  • Talita Antunes Guimarães, Lucyana Conceição Farias, +10 authors André Luiz Sena Guimarães
  • Medicine
  • Oncotarget
  • 2016 (First Published: 23 August 2016)
  • BACKGROUND Metformin is a biguanide, belonging to the oral hypoglycemic agents and is a widely used in the treatment of type 2 diabetes. Evidence indicate that Metformin inhibits cell proliferationContinue Reading
  • Talita Antunes Guimarães, Lucyana Conceição Farias, +6 authors André Luiz Sena Guimarães
  • Biology, Medicine
  • Anti-cancer drugs
  • 2016 (First Published: 1 June 2016)
  • The purpose of the current study was to develop and test a theoretical model that could explain the mechanism of action of gallic acid (GA) in the oral squamous cell carcinoma context for the firstContinue Reading
  • Eliane Macedo Sobrinho Santos, Talita Antunes Guimarães, +9 authors Lucyana Conceição Farias
  • Biology, Medicine
  • Tumour biology : the journal of the International…
  • 2017 (First Published: 1 April 2017)
  • Leptin, one of the main hormones controlling energy homeostasis, has been associated with different cancer types. In oral cancer, its effect is not well understood. We investigated, through in vitroContinue Reading
  • Eliane Macedo Sobrinho Santos, Rogério Gonçalves da Rocha, +10 authors Lucyana Conceição Farias
  • Medicine, Biology
  • Pathology, research and practice
  • 2017 (First Published: 1 December 2017)
  • Gallic acid is a polyphenolic compost appointed to interfere with neoplastic cells behavior. Evidence suggests an important role of leptin in carcinogenesis pathways, inducing a proliferativeContinue Reading
  • Patrícia Luciana Batista Domingos, Marcela Gonçalves de Souza, +7 authors André Luiz Sena Guimarães
  • Biology, Medicine
  • Pathology, research and practice
  • 2017 (First Published: 1 May 2017)
  • OBJECTIVE The purpose of the current study is to investigate the association between E-cadherin methylation status, hypoxia and OSCC. METHODS HaCat and SCC9 cell lines were submitted to hypoxicContinue Reading