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Interleukin-6–Signal Transducer and Activator of Transcription-3 Signaling Mediates Aortic Dissections Induced by Angiotensin II via the T-Helper Lymphocyte 17–Interleukin 17 Axis in C57BL/6 Mice
TLDR
The results indicate that the IL-6–signal transducer and activator of transcription-3 signaling pathway converges on Th17 recruitment and IL-17A signaling upstream of macrophage recruitment, mediating aortic dissections. Expand
Pioglitazone-Induced Reductions in Atherosclerosis Occur via Smooth Muscle Cell–Specific Interaction With PPAR&ggr;
TLDR
Pio attenuates Ang II–induced atherosclerosis via the interaction with SMC-specific PPAR&ggr;, but has no effect on the development of AAAs. Expand
IL‐6 Regulates Extracellular Matrix Remodeling Associated With Aortic Dilation in a Fibrillin‐1 Hypomorphic mgR/mgR Mouse Model of Severe Marfan Syndrome
TLDR
Activation of IL‐6‐STAT3 signaling contributes to aneurysmal dilation in mgR/mgR mice through increased MMP‐9 activity, aggravating extracellular matrix degradation. Expand
Systems biology approaches to understanding Epithelial Mesenchymal Transition (EMT) in mucosal remodeling and signaling in asthma
TLDR
How this complex phenotype is beginning to be understood using systems biology-level approaches through perturbations coupled with high throughput profiling and computational modeling may provide translational strategies to reverse the altered signaling and physiology of refractory asthma. Expand
Calpain Inhibition Attenuates Angiotensin II–induced Abdominal Aortic Aneurysms and Atherosclerosis in Low-density Lipoprotein Receptor–deficient Mice
TLDR
It is concluded that calpain inhibition using BDA-410 attenuated AngII-induced AAA formation and atherosclerosis development in low-density lipoprotein receptor−/− mice. Expand
Dysregulation of RBFOX2 Is an Early Event in Cardiac Pathogenesis of Diabetes.
TLDR
It is shown that the RNA-binding protein RBFOX2 contributes to transcriptome changes under diabetic conditions and is demonstrated to be an early pathogenic event in diabetic hearts. Expand
Coordinate activities of BRD4 and CDK9 in the transcriptional elongation complex are required for TGFβ-induced Nox4 expression and myofibroblast transdifferentiation
TLDR
It is demonstrated that Nox4 is involved in αSMA+ fiber formation and collagen production in primary human dermal fibroblasts using a small-molecule inhibitor and siRNA-mediated silencing and suggested that inhibition of the Smad3-BRD4 pathway may be a useful strategy to limit hypertrophic scar formation after burn injury. Expand
Increasing proportions of tyrosine hydroxylase-immunoreactive interneurons colocalize with choline acetyltransferase or vasoactive intestinal peptide in the developing rat cerebral cortex
TLDR
The results suggest that increasing proportions of cortical TH neurons express ChAT or VIP developmentally and that a subset of these TH neurons may regulate local blood flow. Expand
Deletion of NF-&kgr;B/RelA in Angiotensin II-Sensitive Mesenchymal Cells Blocks Aortic Vascular Inflammation and Abdominal Aortic Aneurysm Formation
TLDR
Fibrogenic mesenchymal RelA plays a causal role in Ang II-induced vascular inflammation and AAA in normolipidemic mice. Expand
Cytokine amplification and macrophage effector functions in aortic inflammation and abdominal aortic aneurysm formation.
TLDR
A sequential "two-hit" model of vascular inflammation involving initial vascular injury followed by recruitment of Ly6C(hi) macrophages is proposed, drawing from previous studies implicating a similar essential role for IL-6 signaling in macrophage activation, Th17 expansion and aortic dissections. Expand
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