The Blood Pressure-Lowering Effect and Safety of Chlorogenic Acid from Green Coffee Bean Extract in Essential Hypertension
CGA from GCE is effective in decreasing blood pressure and safe for patients with mild hypertension and there was no difference in body mass index and pulse rate between groups, nor were there any apparent side effects.
Synergistic Effect of Urotensin II With Mildly Oxidized LDL on DNA Synthesis in Vascular Smooth Muscle Cells
The results suggest that UII acts synergistically with moxLDL in inducing VSMC proliferation via the c-Src/PKC/MAPK pathway, which may explain the relatively rapid progression of atherosclerosis in patients with hypertension and hypercholesterolemia.
Salusins: Potential Use as a Biomarker for Atherosclerotic Cardiovascular Diseases
- Kengo Sato, Rena Watanabe, F. Itoh, M. Shichiri, Takuya Watanabe
- Biology, MedicineInternational Journal of Hypertension
- 22 October 2013
Findings suggest that salusin-β and salus in-α may contribute to proatherogenesis and antiatherogenisation, respectively, and could be candidate biomarkers and therapeutic targets for atherosclerotic cardiovascular diseases.
Impact of Salusin-α and -β on Human Macrophage Foam Cell Formation and Coronary Atherosclerosis
The results indicate that the 2 salusin isoforms have opposite effects on foam cell formation in human monocyte-derived macrophages, and development of atherosclerosis may be accelerated bysalusin-β and suppressed by saluin-α via ACAT-1 regulation.
A selective ACAT-1 inhibitor, K-604, suppresses fatty streak lesions in fat-fed hamsters without affecting plasma cholesterol levels.
Adropin Contributes to Anti-Atherosclerosis by Suppressing Monocyte-Endothelial Cell Adhesion and Smooth Muscle Cell Proliferation
- Kengo Sato, Tomoyuki Yamashita, Takuya Watanabe
- Biology, MedicineInternational Journal of Molecular Sciences
- 26 April 2018
Chronic administration of adropin to Apoe−/− mice attenuated the development of atherosclerotic lesions in the aorta, with reduced the intra-plaque monocyte/macrophage infiltration and smooth muscle cell content, and could serve as a novel therapeutic target in atherosclerosis and related diseases.
Human Urotensin II Accelerates Foam Cell Formation in Human Monocyte-Derived Macrophages
The results suggest that U-II may play a novel role in the formation of macrophage-derived foam cells by upregulating ACAT-1 expression via the UT receptor/G-protein/c-Src/PKC/MEK and ROCK pathways but not by SR-A, thus contributing to the relatively rapid development of atherosclerosis in hypertension.
A glucagon-like peptide-1 analog liraglutide suppresses macrophage foam cell formation and atherosclerosis
Human Urotensin II as a Link between Hypertension and Coronary Artery Disease
- Takuya Watanabe, T. Kanome, A. Miyazaki, T. Katagiri
- Biology, MedicineHypertension Research
- 1 June 2006
Findings suggest that U-II plays key roles in accelerating the development of atherosclerosis, thereby leading to coronary artery disease.
Relationship Between Serum Insulin‐Like Growth Factor‐1 Levels and Alzheimer's Disease and Vascular Dementia
- Takuya Watanabe, A. Miyazaki, T. Katagiri, Hideki Yamamoto, T. Idei, T. Iguchi
- MedicineJournal of The American Geriatrics Society
- 1 October 2005
To determine whether decreased serum insulin‐like growth factor‐1 (IGF‐1) levels could be a risk factor for dementia in older people, a study of serum IGF‐1 levels in patients with Alzheimer's disease is conducted.