Takuro Tomita

Learn More
The process of store-operated Ca(2+) entry (SOCE), whereby Ca(2+) influx across the plasma membrane is activated in response to depletion of intracellular Ca(2+) stores in the endoplasmic reticulum (ER), has been under investigation for greater than 25 years; however, only in the past 5 years have we come to understand this mechanism at the molecular level.(More)
Recent studies have defined roles for STIM1 and Orai1 as calcium sensor and calcium channel, respectively, for Ca(2+)-release activated Ca(2+) (CRAC) channels, channels underlying store-operated Ca(2+) entry (SOCE). In addition, these proteins have been suggested to function in signalling and constructing other channels with biophysical properties distinct(More)
Several studies have shown that the ruminative responses, which are defined as a coping pattern that focuses on the symptoms of depression and on the possible causes and consequences of these symptoms, are associated with depression. Recently, negative rumination, which is defined as the tendency to continue to think about something bad, harmful, or(More)
Bereavement-induced grief and psychological intervention are important social issues and worthy of greater attention from researchers and clinicians. Here, we review currently available measures of grief and discusses the differentiation of normal grief reaction from pathological grief and major depression. Finally, we propose future directions for research(More)
Store-operated calcium entry is an almost ubiquitous signaling pathway in eukaryotic cells. The plasma membrane store-operated channels are comprised of subunits of the recently discovered Orai proteins, the major one being Orai1.We have discovered that native Orai1, as well as expressed Orai1, exists in two forms in similar quantities: a longer form(More)
In a cloud computing environment, it is necessary to simultaneously allocate both processing ability and network bandwidth needed to access it. The authors proposed the congestion control method for a cloud computing environment which reduces the size of required resource for congested resource type, instead of restricting all service requests as in the(More)
Although several studies have indicated that persons with a high ruminative coping style experience higher depression after the loss of a loved one, the relationship between ruminative coping and the occurrence of clinical depression and anxiety disorders after a loss has not been thoroughly investigated. This study investigated the relationship between(More)
roles in regulating cell functions such as chemotaxis, motility or secretion. Stimulation by neurotransmitters or hormones activates intracellular production of inositol 1, 4, 5-trisphosphate (IP3) and diacylglycerol (DAG). IP3 binds to the IP3 receptor on the Ca store (endoplasmic reticulum ; ER) membrane and releases the sequestered Ca to the(More)
The purpose of this study was to examine the factor structure in the Temperament and Character Inventory [TCI; Cloninger, C. R., Svrakic, D. M., & Przybeck, T. R. (1993). A psychobiological model of temperament and character. Archives of General Psychiatry, 50, 975±990.] and to determine appropriate subscales and items to assess the psychobiological(More)
  • 1