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  • Masayuki Takahashi, Takuo Washio, Norio Suzuki, Katsuhiro Igeta, Shinji Yamashita
  • Chemistry, Medicine
  • Journal of pharmaceutical sciences
  • 2009 (First Publication: 1 November 2009)
  • In order to elucidate the causes of the species differences in the oral bioavailability (BA) between cynomolgus monkeys and humans, the contributions of first-pass metabolism and intestinalContinue Reading
    The pharmacokinetics and metabolism of SNI-2011 ((+/-)-cis-2-methylspiro[1,3-oxathiolane-5,3'-quinuclidine]monohydrochloride hemihydrate, cevimeline, CAS 153504-70-2), a novel muscarinicContinue Reading
  • Masayuki Takahashi, Takuo Washio, Norio Suzuki, Katsuhiro Igeta, Shinji Yamashita
  • Biology, Medicine
  • Biological & pharmaceutical bulletin
  • 2010
  • To clarify the causes of low oral bioavailability (BA) of drugs in cynomolgus monkeys, the experimental method to evaluate the drug permeability and the metabolism in the intestine of cynomolgusContinue Reading
  • Nobuya Inagaki, Hubert S. Chou, +4 authors Takashi Taguchi
  • Medicine
  • BMJ open diabetes research & care
  • 2017 (First Publication: 1 September 2017)
  • OBJECTIVE DS-8500a is a novel G protein-coupled receptor 119 agonist being developed for the treatment of type 2 diabetes. The study objective was to assess the efficacy and safety of DS-8500a inContinue Reading
  • Makiko Yamada, Makoto Takei, +6 authors Takashi Izumi
  • Chemistry, Medicine
  • Xenobiotica; the fate of foreign compounds in…
  • 2017 (First Publication: 2 December 2017)
  • 1. Esaxerenone (CS-3150) is a novel non-steroidal mineralocorticoid receptor antagonist. The pharmacokinetics, tissue distribution, excretion, and metabolism of esaxerenone were evaluated in rats andContinue Reading
  • Yuichiro Yamada, Yasuo Terauchi, +4 authors Takashi Taguchi
  • Medicine
  • Advances in Therapy
  • 2018 (First Publication: 1 March 2018)
  • IntroductionG protein-coupled receptor 119 (GPR119) is a promising target for the treatment of type 2 diabetes mellitus (T2DM), as both insulin and glucagon-like peptide-1 secretion can be promotedContinue Reading
  • Yasuo Terauchi, Yuichiro Yamada, +4 authors Takashi Taguchi
  • Medicine
  • Journal of diabetes investigation
  • 2018 (First Publication: 1 November 2018)
  • INTRODUCTION We evaluated the efficacy and safety of DS-8500a as add-on therapy to sitagliptin in Japanese type 2 diabetes mellitus patients. MATERIALS AND METHODS This multicenter, randomized,Continue Reading