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CONTEXT Weekly teriparatide injection at a dose of 56.5 μg has been shown to increase bone mineral density. OBJECTIVE A phase 3 study was conducted to determine the efficacy of once-weekly teriparatide injection for reducing the incidence of vertebral fractures in patients with osteoporosis. DESIGN AND SETTING In this randomized, multicenter,(More)
A new computerized apparatus was constructed to measure the resonant frequency of human ulnain vivo with high sensitivity and reproducibility. Experimental studies using aluminum bar and dried human bone revealed the importance of the ulna being positioned parallel to the radius, approximately 90 degree flexion of the elbow joint, and minimal muscle(More)
  • Yasuki Hashimoto, Masaaki Fukase, +5 authors Takuo Fujita
  • 2006
Effect of oral calcium load on calcium metabolism was studied in 6 healthy subjects. Calcium carbonate (3.75 g) and Oyster Shell Electrolysate (OSE, 3.0 g) were orally administrated in a cross-over design to provide 1.5 g elementary calcim to each subject twice at 1 week interval. No significant differences were found in the increments of serum calcium,(More)
A total of 127 patients with involutional osteoporosis were randomly divided into two groups. The elcatonin group consisted of 67 patients who received 20 units of elcatonin per week administered intramuscularly, together with 0.6g calcium lactate (100mg as calcium) given orally three times daily for 24 weeks. The other 60 patients were assigned to a(More)
L-ascorbic acid at physiological concentrations (10 μg/ml) increased alkaline phosphatase activity in the osteoblastlike rat osteosarcoma cell line, UMR-106. The increase was dose-dependent and detectable at 6 hours after the addition of 100 μg/ml ascorbic acid to the medium. Treatment of the cells with 100 μg/ml ascorbic acid potentiated the response of(More)
Back and knee pain is a widespread health problem and a serious threat to the quality of life (QOL) in middle-aged and older adults, as it frequently accompanies osteoporosis and osteoarthritis. In order to compare the effects of elcatonin and risedronate on such pain, 20 units of elcatonin was intramuscularly injected to 18 patients, and 5 mg of(More)
Two patients with severe iron deficiency anemia and gastric antral vascular ectasia (GAVE) are reported. The anemia caused by the chronic blood loss from the abnormally dilated mucosal and submucosal capillary veins in the gastric antrum was unresponsive to oral iron supplementation. However, one of the patients was successfully treated with intramuscular(More)
The swaying and postural instability frequently seen in elderly subjects had not been analyzed quantitatively in detail until the introduction of computerized posturography. In order to assess the changes of body sway with aging, we performed computerized posturography in 144 subjects (51 men and 93 women, between the ages of 22 and 88 years) without(More)
Bone mineral measurements of the 2nd and 3rd vertebrae were made using dual energy x-ray absorptiometry (DEXA) in both antero-posterior (AP) and lateral (Lat) projections in 49 women (Group I; 24 young controls, II; 11 elderly controls, III; 14 osteoporotics). The coefficients of variation of the AP and Lat measurements of BMC in 3 young women were 2.2% and(More)
We have performed the immunohistochemical analysis for PTHrP expression in normal and 60 lung, 108 uterine, 28 breast, 42 renal, 22 ovarian and 33 gastric neoplastic tissues. Normal epithelial tissues, such as keratinocytes, renal tubules and mammary ductal cells showed positive immunoreactivity. In lung cancer, squamous (94%) and small cell (89%) carcinoma(More)