Takumasa Yoshida

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OBJECTIVE The prominent side-effect of cyclosporin A, an immunosuppressive drug, in oral tissues is gingival outgrowth, although the exact mechanism underlying this side-effect is unclear. The main purposes of the present study were to determine whether cyclosporin A induced the gingival outgrowth by promoting proliferation of gingival cells and whether(More)
BACKGROUND Volatile sulfur compounds (VSCs) produced inside the mouth are a well-known cause of halitosis. Recent studies have suggested that VSCs modify the pathology of periodontitis by encouraging the migration of bacterial toxins associated with increased permeability of gingival epithelia, and enhancing the production of matrix metalloproteinases in(More)
AIM The purpose of this study was to clarify detection characteristics of the secondary mesio-buccal canal in maxillary first molars using various methods. MATERIALS AND METHODS The root canal system of 86 extracted human maxillary first molars was inspected using micro-focus-computed tomography to accurately determine the number of canals. Radiographs or(More)
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