Takuma Kobayashi

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Dorsal and ventral specification in the early optic vesicle plays a crucial role in vertebrate ocular morphogenesis, and proper dorsal-ventral polarity in the optic vesicle ensures that distinct structures develop in separate domains within the eye primordium. The polarity is determined progressively during development by coordinated regulation of(More)
The vertebrate eye develops from the optic vesicle (OV), a laterally protrusive structure of the forebrain, by a coordinated interaction with surrounding tissues. The OV then invaginates to form an optic cup, and the lens placode develops to the lens vesicle at the same time. These aspects in the early stage characterize vertebrate eye formation and are(More)
Twenty-two patients with malignant melanoma were treated with boron neutron capture therapy (BNCT) using10B-p-boronophenylalanine (BPA). The estimation of absorbed dose and optimization of treatment dose based on the pharmacokinetics of BPA in melanoma patients is described. The doses of γ-rays were measured using small TLDs of Mg2SiO4 (Tb) and thermal(More)
Event-related potentials (ERPs) in silent speech using the vowel /a/ were recorded from 12 scalp electrodes and three electrodes monitoring eye and throat movements in eight subjects cued by one of two randomly lit light-emitting diodes (LEDs). The average silent-speech potential minus nonsilent-speech potential showed two significant scalp potential(More)
PURPOSE To investigate the effect of low-addition soft contact lenses (CLs) with decentered optical design on the progression of myopia in children in a pilot study. SUBJECTS AND METHODS Twenty-four Japanese children age 10-16 years with baseline myopia of -0.75 to -3.50 D sphere and ≤1.00 D cylinder were studied. The new CLs were designed to have a nasal(More)
BACKGROUND: There is insufficient information regarding patient-based outcomes after knee arthrodesis following infected total knee arthroplasty (TKA). The purpose of this study was to analyze outcomes in patients who underwent knee arthrodesis following infected TKA using clinical and radiographic measurements including a patient-based outcome measuring(More)
STUDY DESIGN Using fresh cadavers, the biomechanical testing were used to examine the pullout strength of each pedicle screw. OBJECTIVE The aim of this study was to evaluate pullout strength of (1) a redirected pedicle screw following lateral wall breach; (2) a redirected pedicle screw following end-plate breach; and (3) a pedicle without redirection(More)
Techniques for fast, noninvasive measurement of neuronal excitability within a broad area will be of major importance for analyzing and understanding neuronal networks and animal behavior in neuroscience field. In this research, a novel implantable imaging system for fluorescence potentiometry was developed using a complementary metal-oxide semiconductor(More)
Measurement of brain activity in multiple areas simultaneously by minimally invasive methods contributes to the study of neuroscience and development of brain machine interfaces. However, this requires compact wearable instruments that do not inhibit natural movements. Application of optical potentiometry with voltage-sensitive fluorescent dye using an(More)
We demonstrate wireless image data transmission through a mouse brain. The transmission characteristics of mouse brain is measured. By inserting electrodes into the brain, the transmission efficiency is drastically increased. An AM signal modulated with the image data from an implantable image sensor was launched into the brain and the received signal was(More)