Takuji Iwase

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BACKGROUND The impact of sentinel lymph node biopsy on breast cancer mimicking ductal carcinoma in situ (DCIS) is a matter of debate. METHODS We studied the rate of occurrence of sentinel lymph node metastasis in 255 breast cancer patients with pure DCIS showing no invasive components on routine pathological examination. We compared this to the rate of(More)
The architectural distortion is a very important finding in interpreting breast cancers as well as microcalcification and mass on mammograms. However, it is more difficult for physicians to detect architectural distortion than microcalcification and mass. The purpose of this study is to develop two detection approaches for architectural distortions existing(More)
Introduction The incidence of breast cancer has increased greatly in Japan over the past 2 decades [1], and it has been estimated that breast cancer would become the most common malignant disease in Japanese females by the year 2000 [2]. One of the main risk factors for breast cancer in menopausal women is obesity [3,4]. The increased amount of adipose(More)
To investigate possible relationships between genetic alterations and hormonal deregulation during breast cancer development and/or progression, we examined 616 primary breast cancers for loss of heterozygosity (LOH) at chromosomal regions 16q24, 17p13.3 and 17q21, and for amplifications of the ERBB2 and c-MYC loci. A comparison of oestrogen receptor (ER)(More)
BACKGROUND The one-step nucleic acid amplification (OSNA) assay is a molecular-based lymph-node metastasis detection procedure that can assess a whole node and yields semi-quantitative results for the detection of clinically relevant nodal metastases. We aimed to determine the performance of the OSNA assay as an accurate nodal staging tool in comparison(More)
BACKGROUND A standard intra-operative procedure for assessing sentinel lymph node metastasis in breast cancer patients has not yet been established. PATIENTS AND METHODS One hundred and thirty-eight patients with stage I breast cancer who underwent sentinel node biopsy using both imprint cytology and frozen section were analyzed. RESULTS Seventeen of(More)
BACKGROUND Skeletal metastases are often accompanied by bone pain. To investigate the clinical meaning of bone pain associated with skeletal metastasis in breast cancer patients after surgery, we explored whether the presence of bone pain was due to skeletal-related events (SREs) or survival (cause specific death, CSD), retrospectively. METHODS(More)