Takuhiro Nishio

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An improved model of the cooperative binding of monomeric ligands to a linear lattice is proposed for the analysis of surfactant association on the polymer. The interaction between bound ligands across an unoccupied site as well as the steric hindrance effect in consecutive bindings is taken into account here. Typical results of the model calculations are(More)
Monte Carlo simulations of the potentiometric titration are carried out for (carboxymethyl)cellulose in aqueous salt solutions by a previously developed method. A nearly elliptic cylinder with spherical ionizable groups is assumed as model of (carboxymethyl)cellulose molecule. The spherical charges with a hard core potential are adopted as mobile hydrated(More)
The cooperative binding of monomeric ligands to a long lattice of a linear polymer with complete or partial steric hindrance is treated using a matrix method. Results and typical calculations of the model are represented. Non-saturated cooperative binding as well as two-step (biphasic) binding isotherms can be interpreted by the steric hindrance model. This(More)
Electrical conductance and other solution properties of aqueous solutions of a fluorine-containing poly(carboxylic acid), (poly(9H,9H-perfluoro-2,5-dimethyl-3,6-dioxa-8-nonenoic acid), PPFNA) were studied with special attention to the salt effect. This polymer dissociated strongly resulting in a low pH value in unneutralized state (beta=0, beta: degree of(More)
Currently a trial-and-error approach is employed to determine the most effective antiepileptic drug (AED) and dosage for a patient, and almost 30% of all patients are resistant to AED therapy. Introduction of personalized medicine for epilepsy based on pharmacogenomic testing is a new avenue for optimizing AED therapy. However, several crucial issues remain(More)
A numerical method is presented for analysing the potentiometric titration behavior of linear polyelectrolytes. A polyelectrolyte molecule is treated as a one-dimensional lattice containing a large number of lattice points, each of which has an identical ionizable group. In this method, the polyelectrolyte model lattice is divided into identical repeating(More)