Taku Yamashita

Learn More
This article has not been copyedited and formatted. The final version may differ from this version. Abstract Most malignant tumors are derived from epithelium, and claudin (CLDN)-3 and-4 are frequently overexpressed in such tumors. Although antibodies have potential in cancer diagnostics and therapy, development of antibodies against CLDNs has been(More)
PURPOSE Poly(ADP-ribose) polymerases (PARP) and the Mre11, Rad50, and Nbs1 (MRN) complex are key regulators of DNA repair, and have been recently shown to independently regulate telomere length. Sensitivity of cancers to PARPi is largely dependent on the BRCAness of the cells. Unfortunately, the vast majority of cancers are BRCA-proficient. In this study,(More)
Since the Great East Japan Earthquake, when energy supply and balance issues began to attract public attention, various power saving approaches have taken root in our life. Besides human factor-related approaches such as turning off switches when electrical appliances are not in use and changing the temperature settings of air conditioners, solutions based(More)
Improved therapies for individuals with head and neck squamous cell carcinoma (HNSCC) may be developed by identification of appropriate biomarkers. The aim of this study was to evaluate the usefulness of serum midkine measurement as a biomarker for HNSCC. Pretreatment serum midkine concentrations were measured in 103 patients with HNSCC and 116 control(More)
Activator protein-1 (AP-1) is a transcriptional factor that regulates the expression of various genes associated with tumor invasion and migration. The purpose of our study was to assess the therapeutic effects of a novel selective AP-1 inhibitor, T-5224, in preventing lymph node metastasis in head and neck squamous cell carcinoma (HNSCC) in an orthotopic(More)
Acquired tracheal stenosis remains a challenging problem for otolaryngologists. The objective of this study was to determine whether the Sendai virus (SeV)-mediated c-myc suppressor, a far upstream element (FUSE)-binding protein (FBP)-interacting repressor (FIR), modulates wound healing of the airway mucosa, and whether it prevents tracheal stenosis in an(More)
In spite of the fact that systems are ever growing in size, the demand for a short development cycle and high system reliability remains unchanged. Web services are drawing attention as a solution to such a demand. Another approach to developing a program in a short time is STAR (SofTware Architecture using Rule-based language). STAR uses a rule-based(More)
OBJECTIVE Intratympanic gentamicin injection (ITGI) has gained acceptance worldwide for the treatment of Ménière's disease. Reports assessing the efficacy of ITGI suffer from high variability between patients. This variability may be due to ITGI, which does not permit a sustained diffusion of gentamicin across the round window membrane. The present study(More)
  • 1