Taku Takeuchi

Learn More
PURPOSE RECK, a membrane-anchored regulator of matrix metalloproteinases (MMPs), is widely expressed in healthy tissue, whereas it is expressed at lower levels in many tumor-derived cell lines. Studies in mice and cultured cells have shown that restoration of RECK expression inhibits tumor invasion, metastasis, and angiogenesis. However, the clinical(More)
Nuclear factor kappa B (NF-kappa B) is a transcription factor that is known to regulate apoptosis when cells are exposed to DNA-damaging agents such as ionizing radiation and cytotoxic drugs. We sought to determine if inhibition of NF-kappa B could enhance radiosensitivity in human colon cancer cells in vitro and in vivo. To inhibit NF-kappa B activation(More)
OBJECT Detachable platinum coils are widely used in the endovascular treatment of intracranial aneurysms. The use of coil placement produces a higher incidence of aneurysm recurrence compared with surgical clipping. To reduce the incidence of recurrence by promoting clot organization, the authors designed a platinum coil coated with tenascin-C (TNC), an(More)
We construct a protostellar disk model that takes into account the combined effect of viscous evolution, photoevaporation and the differential radial motion of dust grains and gas. For T Tauri disks, the lifetimes of dust disks that are mainly composed of millimeter sized grains are always shorter than the gas disks’ lifetimes, and become similar only when(More)
From millimeter observations of classical T Tauri stars, it is suggested that dust grains in circumstellar disks have grown to millimeter size or larger. However, gas drag on such large grains induces rapid accretion of the dust. We examined the evolution of dust disks composed of millimeter sized grains, and showed that rapid accretion of the dust disk(More)
5-Fluorouracil (5-FU) is one of the most widely used chemotherapeutic agents, and is known to be a radiosensitizer. Previously, we reported that adenoviral transduction of the Escherichia coli (E. coli) uracil phosphoribosyltransferase (UPRT) gene induced marked sensitivity in human colon cancer cells to 5-FU. The aim of the current study was to investigate(More)
Astrometric detection of a stellar wobble on the plane of the sky will provide us a next breakthrough in searching extrasolar planets. The Space Interferometry Mission (SIM) is expected to achieve a high-precision astrometry as accurate as 1 μas, which is precise enough to discover a new-born Jupiter mass planet around a pre-main-sequence (PMS) star in the(More)