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Synthesis and evaluation of radioiodinated (S,S)-2-(α-(2-iodophenoxy)benzyl)morpholine for imaging brain norepinephrine transporter
TLDR
The synthesis of (S,S)-123I-IPBM is a potential SPECT radiopharmaceutical for imaging brain NET and shows high affinity and selectivity for NET in the binding assay experiments.
18F-FDG PET and intravascular ultrasonography (IVUS) images compared with histology of atherosclerotic plaques: 18F-FDG accumulates in foamy macrophages
TLDR
F-FDG PET localized and quantified the degree of infiltration of foamy macrophages in atherosclerotic lesions and is a promising imaging technique for evaluating atherosclerosis and for monitoring changes in the composition of atheroscerotic plaques affecting their stability.
Evaluation of radioiodinated (2S,alphaS)-2-(alpha-(2-iodophenoxy)benzyl)morpholine as a radioligand for imaging of norepinephrine transporter in the heart.
TLDR
In vitro binding assays showed that the affinity of (S,S)-IPBM to NET was similar to those of the well-known NET-specific binding agents, nisoxetine and desipramine, but not by dopamine or serotonin transporter binding agents.
Glucose uptake of the muscle and adipose tissues in diabetes and obesity disease models: evaluation of insulin and β3-adrenergic receptor agonist effects by 18F-FDG
TLDR
The biodistribution method with 18F-FDG was confirmed to be useful for pharmacological evaluation of anti-diabetic or anti-obesity drugs using disease-model animals to detect clear differences in basal glucose uptake between disease- model animals and their corresponding controls.
Detection of atherosclerotic lesions in apolipoprotein E knockout mice using USPIO-enhanced magnetic resonance imaging.
TLDR
Mika Murabayashi1, Taku Sugita1, Keiko Hirakawa2,3, Hideto Kuribayashi4, Ikuo Mori1, Kazuki Kubo1, Takashi Horiguchi1, and Yasuo Katayama2,5.
Biodistribution studies for cell therapy products: Current status and issues
TLDR
This review aimed at surveying international and Japanese trends concerning the BD study for CTPs and the following subjects were investigated, which were considered particularly important.
Evaluation of drug effects on cerebral blood flow and glucose uptake in un-anesthetized and un-stimulated rats: application of free-moving apparatus enabling to keep rats free during PET/SPECT tracer
TLDR
Free-moving 18F-FDG-PET and 99mTc-HMPAO-SPECT imaging systems are successfully developed and detected detailed glucose uptake and cerebral blood flow changes in the conscious rat brain with fluoxetine administration.