Taketoshi Yoshida

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Providing humoral immunity, antibody-secreting plasma cells and their immediate precursors, the plasmablasts, are generated in systemic and mucosal immune reactions. Despite their key role in maintaining immunity and immunopathology, little is known about their homeostasis. Here we show that plasmablasts and plasma cells are always detectable in human blood(More)
One of the main themes in text mining is text representation, which is fundamental and indispensable for text-based intellegent information processing. Generally, text representation inludes two tasks: indexing and weighting. This paper has comparatively studied TF IDF, LSI and multi-word for text representation. We used a Chinese and an English document(More)
0957-4174/$ see front matter 2009 Elsevier Ltd. A doi:10.1016/j.eswa.2009.02.026 * Corresponding author. E-mail addresses: zhangwen@jaist.ac.jp (W. Zh Yoshida), xjtang@amss.ac.cn (X. Tang). One of the deficiencies of mutual information is its poor capacity to measure association of words with unsymmetrical co-occurrence, which has large amounts for(More)
Cleidocranial dysplasia (CCD) is an autosomal dominant heritable skeletal disease caused by heterozygous mutations in the osteoblast-specific transcription factor RUNX2. We have performed mutational analysis of RUNX2 on 24 unrelated patients with CCD. In 17 patients, 16 distinct mutations were detected in the coding region of RUNX2: 4 frameshift, 3(More)
Frequent itemset originates from association rule mining. Recently, it has been applied in text mining such as document categorization, clustering, etc. In this paper, we conduct a study on text clustering using frequent itemsets. The main contribution of this paper is three manifolds. First, we present a review on existing methods of document clustering(More)
Following tetanus vaccination, a wave of antibody-secreting cells appear in the peripheral blood composed of vaccine-specific, migratory plasmablasts and plasma cells secreting antibodies specific for other antigens. The latter probably were tissue resident plasma cells formed in earlier immune responses that are mobilized due to competition with the newly(More)
Text representation, which is a fundamental and necessary process for text-based intelligent information processing, includes the tasks of determining the index terms for documents and producing the numeric vectors corresponding to the documents. In this paper, multi-word, which is regarded as containing more contextual semantics than individual word and(More)
BACKGROUND Transforming growth factor (TGF)-beta has a crucial effect on IgA production, which is the major humoral effector of mucosal immunity. Breast milk contains the abundant amount of TGF-beta in the early period of lactation. AIM-STUDY DESIGN: To verify the notion that TGF-beta in breast milk might contribute to the development of IgA production in(More)
Immunological memory, as provided by antibodies, depends on the continued presence of antibody-secreting cells, such as long-lived plasma cells of the bone marrow. Survival niches for these memory plasma cells are limited in number. In an established immune system, acquisition of new plasma cells, generated in response to recent pathogenic challenges,(More)