Takeshi Oshima

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The endolymphatic calcium concentration [Ca2+] is essential for acoustic transduction. This study investigated the changes in cochlear function caused by vestibular labyrinth destruction in the acute phase by measurement of the endocochlear potential and endolymphatic [Ca2+].Hartley guinea pigs underwent lateral semicircular canal transection with(More)
PURPOSE To determine whether injured corneal epithelial cells stimulate myodifferentiation in corneal fibroblasts and whether transforming growth factor (TGF)-beta is involved. METHODS Rabbit corneal fibroblasts were cultured on collagen gel, with or without cocultured corneal epithelial cells or with partially scraped epithelial cells, on a companion(More)
OBJECTIVE Nasal-noise masking audiometry was developed to assess the acoustic transfer function from the nasopharyngeal cavity to the middle ear via patulous eustachian tube (ET). STUDY DESIGN Prospective. SETTING Tertiary referral center. PATIENTS Twenty-seven ears of 18 patients with patulous ET and 20 ears of 10 healthy subjects with no history of(More)
Recently, we reported that homozygous males and females of a mouse model of DFN3 non-syndromic deafness generated by the deletion of Brn-4 transcription factor showed profound deafness due to severe alterations in the cochlear spiral ligament fibrocytes from the age of 11 weeks, whereas no hearing loss was recognized in young female heterozygotes. It is(More)
OBJECTIVES Evaluation of the effect of conservative and surgical treatment in patients with patulous Eustachian tube (PET) associated with habitual sniffing. STUDY DESIGN Retrospective case review. SETTING University hospital otolaryngology department. PATIENTS Ninety-seven (23.4%) of 414 PET patients were found to have habitual sniffing to alleviate(More)
Perturbation of cochlear microcirculation, that is, ischemia is a major cause of hearing impairment. Earlier studies examined the short-term (≤7 days) effect of cochlear ischemia. This study characterized the long-term (4 weeks) functional and morphological changes in adult guinea pig cochleae subject to transient ischemia by clamping the labyrinthine(More)
OBJECTIVE Computed tomography (CT) in the sitting position was useful for detecting patulous Eustachian tube (ET). STUDY DESIGN Retrospective. SETTING Tertiary referral center. PATIENTS Eighty-seven patients divided into two groups. The patulous ET group consisted of 111 ears of 67 patients with patulous ET. The control group consisted of 30 ears of(More)
Reverse transcription-polymerase chain reaction demonstrated the expression of heme oxygenase-1 and heme oxygenase-2 (HO-2) mRNA in the cochlea, but the former was considered to be much lower than the latter. The HO-2-like immunoreactivity was observed mainly in supporting cells in the organ of Corti and in the spiral ganglion cells. However, in the(More)