Takeshi Ogihara

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OBJECTIVE The activation of beta-cell genes, particularly of those encoding preproinsulin, requires an appropriate euchromatin (or "open") DNA template characterized by hypermethylation of Lys4 of histone H3. We hypothesized that this modification is maintained in islet beta-cells by the action of the histone methyltransferase Set7/9. RESEARCH DESIGN AND(More)
1 OBJECTIVE—Recent studies identified accumulation of reac-tive oxygen species (ROS) as a common pathway causing insulin resistance. However, whether and how the reduction of ROS levels improves insulin resistance remains to be elucidated. The present study was designed to define this mechanism. RESEARCH DESIGN AND METHODS—We investigated the effect of(More)
Requirement to describing software development processes in formal manners has been increased, and demand for altering and tailoring the process descriptions has been emerged. In this paper, we propose a functional language PDL (Process Description Language), designed to describe various development processes under a certain environment. To create and(More)
Over 200 million people worldwide suffer from diabetes, a disorder of glucose homeostasis. The majority of these individuals are diagnosed with type 2 diabetes. It has traditionally been thought that tissue resistance to the action of insulin is the primary defect in type 2 diabetes. However, recent longitudinal and genome-wide association studies have(More)
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