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  • Makoto Hayashi, Eiichi Kamata, Akihiko Hirose, Mika Takahashi, Takeshi Morita, Makoto Ema
  • Biology, Medicine
  • Mutation research
  • 2005 (First Publication: 1 December 2005)
  • Genotoxicity is one of the important endpoints for risk assessment of environmental chemicals. Many short-term assays to evaluate genotoxicity have been developed and some of them are being usedExpand
  • J. Macgregor, R. Froetschl, +14 authors G. E. Johnson
  • Medicine, Biology
  • Mutation research. Genetic toxicology and…
  • 2015 (First Publication: 1 May 2015)
  • This report summarizes the discussion, conclusions, and points of consensus of the IWGT Working Group on Quantitative Approaches to Genetic Toxicology Risk Assessment (QWG) based on a meeting in FozExpand
  • M. Hayashi, J. Macgregor, +10 authors Dave Gibson
  • Biology, Medicine
  • Mutation research
  • 2007 (First Publication: 1 February 2007)
  • The in vivo micronucleus assay working group of the International Workshop on Genotoxicity Testing (IWGT) discussed new aspects in the in vivo micronucleus (MN) test, including the regulatoryExpand
  • Takeshi Morita, Shuichi Hamada, +6 authors Masamitsu Honma
  • Medicine, Biology
  • Mutation research. Genetic toxicology and…
  • 2016 (First Publication: 1 May 2016)
  • Sensitivity and/or specificity of the in vivo erythrocyte micronucleus (MN) and transgenic rodent mutation (TGR) tests to detect rodent carcinogens and non-carcinogens were investigated. TheExpand
  • Takeshi Morita, Atsuko Miyajima, Akiko Hatano, Masamitsu Honma
  • Biology, Medicine
  • Mutation research. Genetic toxicology and…
  • 2014 (First Publication: 15 July 2014)
  • For the in vitro chromosomal aberration (CA) test, the proposed top-concentration limit will be reduced to '10mM or 2mg/mL' (whichever is lower) in the draft revised OECD (r-OECD) test guideline (TG)Expand
  • Takafumi Kimoto, Katsuyoshi Horibata, +31 authors M. Honma
  • Medicine, Biology
  • Mutation research
  • 2016 (First Publication: 15 November 2016)
  • The in vivo mutation assay using the X-linked phosphatidylinositol glycan class A gene (Pig-a in rodents, PIG-A in humans) is a promising tool for evaluating the mutagenicity of chemicals. ApproachesExpand
  • J. Macgregor, R. Froetschl, +14 authors V. Thybaud
  • Biology, Medicine
  • Mutation research. Genetic toxicology and…
  • 2015 (First Publication: 1 May 2015)
  • This is the second of two reports from the International Workshops on Genotoxicity Testing (IWGT) Working Group on Quantitative Approaches to Genetic Toxicology Risk Assessment (the QWG). The firstExpand
  • Kazunori Narumi, Koji Ashizawa, +7 authors Shuichi Hamada
  • Biology, Medicine
  • Mutation research
  • 2012 (First Publication: 18 September 2012)
  • Various liver micronucleus assay methods, such as those involving partial hepatectomy, treatment with mitogens, and the use of juvenile animals, have been developed. These assays have been proven toExpand