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Inhibition of the ATP‐sensitive potassium channel by class I antiarrhythmic agent, cibenzoline, in rat pancreatic β‐cells
1 Cibenzoline, a class I antiarrhythmic agent, was investigated for its effect on the ATP‐sensitive K+ channel of pancreatic β‐cells by the patch clamp technique. 2 In perforated patch clampExpand
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Effect of intraventricular administration of noradrenaline and dopamine on the levels of corticosterone in rats and denervation hypersensitivity resulting from intraventricular administration of
Abstract The effects of intraventricular administration of noradrenaline (NA) on the resting levels, stress-induced rises and dexamethasone-induced decreases of plasma corticosterone (B) were studiedExpand
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Studies on antiulcer agents. IV. Antiulcer effects of 2-benzylthio5,6,7,8-tetrahydro-4(3H)-quinazolinones and related compounds.
With a view to finding more effective antiulcer agents, a series of 2-benzylthio-5,6,7,8-tetrahydro-4(3H)-quinazolinones and related compounds were synthesized and evaluated in a histamine-stimulatedExpand
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Increased sensitivity to 5-hydroxytryptamine due to intraventricular administration of 5,6-dihydroxytryptamine.
The possibility that intraventricular administration of 5,6-dihydroxytryptamine (5,6-DHT) can cause a development of denervation hypersensitivity to central 5-hydroxytryptamine (5-HT) was examined inExpand
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The effects of intraperitoneal injection of 6‐hydroxydopamine on the turnover and the levels of the brain catecholamines and the levels of plasma corticosterone in rats
1. The effects of intraperitoneal injection of 6‐hydroxydopamine (6‐OHDA) on the levels and the turnover of brain catecholamines and the levels of plasma corticosterone were studied in rats.
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Anti-gastric acid secretory mechanism of 1,6-dihydro-2-[2-(2-methylpropoxy)anilino]-6-oxo-5-pyrimidinecarboxylic acid. Effect on mucosal mast cell.
To clarify the anti-gastric acid secretory mechanism of 1,6-dihydro-2-[2-(2-methylpropoxy)anilino]-6-oxo-5-pyrimidinecarbo xylic acid (CAS 98772-05-5, MAR-99), the relationship between gastric acidExpand
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Stimulation by volume expansion of atrial natriuretic peptide release from perfused rat heart
The release of immunoreactive (ir-) rat atrial natriuretic peptide (rANP) with volume expansion in in situ retrograde perfused rat heart was examined. The volume expansion induced by the infusion ofExpand
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Studies on antiulcer agents. II. Antiulcer properties of N-(1H-tetrazol-5-yl)-2-anilino-5-pyrimidinecarboxamides inhibiting release of histamine from passively sensitized rat peritoneal mast cells.
With the aim of applying mast cell-stabilizing agents as antiulcer agents, N-(1H-tetrazol-5-yl)-2-anilino-5-pyrimidinecarboxamides were synthesized, and initially evaluated pharmacologically forExpand
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Modulation of IgE Synthesis by IgE‐Binding Factors Released by T Cells of Asthmatic Patients with Elevated Serum IgE
The culture supernatants of unstimulated T cells (TCS) from asthmatic patients with elevated serum IgE were tested for IgE‐binding factors (IgE‐BFs) displaying the IgE‐potentiating activity. TheExpand
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