Takeshi Imai

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Orthographic variance is a fundamental problem for many natural language processing applications. The Japanese language, in particular, contains many orthographic variants for two main reasons: (1) transliterated words allow many possible spelling variations , and (2) many characters in Japanese nouns can be omitted or substituted. Previous studies have(More)
This article discusses the ontological treatment of diseases in the framework of the Ontology for General Medical Science (OGMS). We aim to provide a definition of a disease that is more friendly to clinicians and propose a corresponding model of diseases. We define a disease as a dependent continuant constituted of one or more causal chains of clinical(More)
Although researchers have shown increasing interest in extracting/classifying semantic relations, most previous studies have basically relied on lexical patterns between terms. This paper proposes a novel way to accomplish the task: a system that captures a physical size of an entity. Experimental results revealed that our proposed method is feasible and(More)
In order to realize sophisticated medical information systems, many medical ontologies have been developed. We proposed a definition of disease based on River Flow Model which captures a disease as a causal chain of clinical disorders. We also developed a disease ontology based on the model. It includes definitions of more than 6,000 diseases with 17,000(More)
We have been building a Japanese medical ontology that provides an intelligent infrastructure for systematization and synthetic understanding of medical knowledge on a large scale. The objectives of our research include building a medical ontology and developing application systems based on it. We identified a few common fundamental technologies for(More)
Vitamin K2 (VK2, menaquinone) is known to have anticancer activity in vitro and in vivo. Although its effect is thought to be mediated, at least in part, by the induction of apoptosis, the underlying molecular mechanism remains elusive. Here, we identified Bcl-2 antagonist killer 1 (Bak) as a molecular target of VK2-induced apoptosis. VK2 directly interacts(More)
* Exchanging medical data and information is important in the medical domain. This paper discusses abnormal states in the definition of diseases. First, we introduce our unified representation framework of abnormal states in a property-decomposed manner, which enables interoperability between clinical data and abnormal states in the definition of diseases.(More)
PURPOSE We evaluate the status of health information system (HIS) adoption (In this paper, "HIS" means electronic medical record system (EMR) and computerized provider order entry system (CPOE)). We also evaluate the affect of the policies of Japanese government. METHODS The status of HIS adoption in Japan from 2002 to 2011 was investigated using reports(More)
BACKGROUND Recently, exchanging data and information has become a significant challenge in medicine. Such data include abnormal states. Establishing a unified representation framework of abnormal states can be a difficult task because of the diverse and heterogeneous nature of these states. Furthermore, in the definition of diseases found in several(More)