Takeshi Hiroe

  • Citations Per Year
Learn More
Endothelins modulate hormonal secretion in the pituitary gland. Intense signaling of endothelin A receptors (ETAR) has been detected by in situ hybridization, binding assay and receptor autoradiography. We used light- and electron-microscopic immunohistochemistry of ETAR with polyclonal antibody against a synthetic peptide corresponding to the carboxyl(More)
Intense expression of mRNA of endothelin-B receptor (ETBR) has been detected in the Bergmann glia of cerebellum by in situ hybridization, but the intracellular localization has not been reported because of the absence of a useful antibody for immunohistochemical investigations. We made polyclonal antibodies against the carboxyl terminus of human ETBR(More)
Subepithelial fibroblasts form a cellular network with gap junctions under the epithelium of the gastrointestinal tract. Previously, we have reported their unique characteristics, such as reversible rapid cell-shape changes from a flat to a stellate configuration induced by dBcAMP and endothelins (ETs), and Ca2+ responses to, for example, ETs, ATP, and(More)
Phosphoinositide-specific phospholipase C (PLC) is a key enzyme in phosphoinositide turnover and is involved in a variety of physiological functions. We analyzed PLCdelta1 knockout mice and found that PLCdelta1 is required for the maintenance of skin homeostasis. However, there were no remarkable abnormalities except hair loss and runting in PLCdelta1(More)
We have previously reported that a mutation in the ankyrin repeats of mouse Notch2 results in embryonic lethality by embryonic day 11.5 (E11.5), showing developmental retardation at E10.5. This indicated that Notch2 plays an essential role in postimplantation development in mice. Here, we demonstrate that whole embryo culture can circumvent developmental(More)
Laboratory of Genome and Biosignal, Tokyo University of Pharmacy and Life Science, 1432-1 Horinouchi, Hachioji, 192-0392 Tokyo, Japan; Tissue and Cell Culture Laboratory, National Institute For Basic Biology, 38 Nishigonaka, Myodaiji, Okazaki, Aichi 444-8585, Japan; Laboratory Animal Center, Ehime University School of Medicine, Shitsukawa, Shigenobu-cho,(More)
We clinically and clinicopathologically investigated the immobilizing and sedative effects of a medetomidine-midazolam (MM) combination in Japanese monkeys (Macaca fuscata) and its antagonism with atipamezole. MM (medetomidine, 60 microg/kg; midazolam, 0.3 mg/kg) was administered intramuscularly to each monkey (n = 11). All animals were laterally recumbent(More)
  • 1