Takeshi Hashizume

  • Citations Per Year
Learn More
The wyeosine (or wye) family of tricyclic ribonucleosides from archaeal and eukaryal tRNA(Phe) constitutes one of the most complex and interesting series of posttranscriptional RNA modifications, and has been the object of numerous studies of their chemical and biological synthesis and distribution. We report the structures of two minimally elaborated wye(More)
Since some antagonists or antidotes in cases of acute poisoning are not commercially available in Japan, in many hospitals they are prepared on their premises for clinical use. However, no specific legislation for the procedures of quality assurance and informed consent of these hospital-prepared products as yet exists. Further, the standard procedures for(More)
The antibacterial activities of 64 naphthyridine derivatives were tested. Ultimately, potassium 1,4-dihydro-1-methyl-7-[2-(5-nitro-2-furyl)vinyl]-4-oxo-1,8 -naphthyridine-3carboxylate (677K) was selected as the most active compound. Compound 677K exhibited excellent antibacterial activities against either gram-positive or gram-negative bacteria in vitro.(More)
  • 1