Approximately 20% of familial amyotrophic lateral sclerosis (FALS) arises from germ-line mutations in the superoxide dismutase-1 (SOD1) gene. However, the molecular mechanisms underlying the process have been elusive. Here, we show that a neuronal homologous to E6AP carboxyl terminus (HECT)-type ubiquitin-protein isopeptide ligase (NEDL1) physically binds… (More)
— This paper focuses on the nematode C. elegans, which has a relatively simple structure, and is one of the most analyzed organisms among multicellular ones. We aim to develop a mathematical model of this organism to analyze control mechanisms with respect to locomotion. First, a new motor control model of the C. elegans is proposed, which includes both of… (More)
The nematode Caenorhabditis elegans (C. elegans), a relatively simple organism in structure, is one of the most well-studied multicellular organisms. We developed a virtual C. elegans based on the actual organism to analyze motor control. We propose a dynamic body model, including muscles, controlled by a neural circuit model based on the actual nematode.… (More)
BACKGROUND Histones play important roles in both host defenses and inflammation related to microbial infection. A peptide mimotope (SSV) was identified from a novel histone H1 monoclonal antibody (16G9 mAb) that was shown to inhibit the mixed lymphocyte reaction. In the present study, an anti-SSV producing hybridoma was established. We investigated the… (More)
Nuclear antigens are known to trigger off innate and adaptive immune responses. Recent studies have found that the complex of nucleic acids and core histones that are derived from damaged cells may regulate allergic responses. However, no fundamental study has been performed concerning the role of linker histone H1 in mast cell-mediated type I… (More)
It is proved that every odd perfect number is divisible by a prime greater than 10 7 .
A positive integer is called a (Ore's) harmonic number if its positive divisors have integral harmonic mean. Ore conjectured that every harmonic number greater than 1 is even. If Ore's conjecture is true, there exist no odd perfect numbers. In this paper, we prove that every odd harmonic number greater than 1 must be divisible by a prime greater than 10 5 .