Takeshi Arai

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Oxytocin (Oxt), a neuropeptide produced in the hypothalamus, is implicated in regulation of feeding. Recent studies have shown that peripheral administration of Oxt suppresses feeding and, when infused subchronically, ameliorates hyperphagic obesity. However, the route through which peripheral Oxt informs the brain is obscure. This study aimed to explore(More)
Ghrelin is the orexigenic peptide produced in the periphery, and its plasma level shows remarkable pre/postprandial changes. Ghrelin is considered a pivotal signal to the brain to stimulate feeding. Hence, characterizing the target neurons for ghrelin in the hypothalamic feeding center and the signaling cascade in the target neurons are essential for(More)
Nesfatin-1 is a neuropeptide localized in hypothalamic paraventricular nucleus (PVN). Previously, we have reported the mechanism of feeding suppression by nesfatin-1, and also reported the ability of nesfatin-1 in regulating stress response and the circadian feeding pattern. Pituitary adenylate cyclase-activating polypeptide (PACAP) is a neuropeptide also(More)
Feeding is regulated by perception in the hypothalamus, particularly the first-order arcuate nucleus (ARC) neurons, of the body's energy state. However, the cellular device for converting energy states to the activity of critical neurons in ARC is less defined. We here show that Na(+),K(+)-ATPase (NKA) in ARC senses energy states to regulate feeding.(More)
Anorexia deteriorates the quality of life in patients with anorexia nervosa, stress disorders, gastrointestinal disorders, and cancer. Pro-opiomelanocortin (POMC) neurons in the hypothalamic arcuate nucleus (ARC), serotonin (5-HT) and its 2C receptor (5-HT2CR) are implicated in anorexia. Rikkunshito, a traditional Japanese medicine, has been used to treat(More)
Hideharu Kurita,* Kai Y. Xu,* Yuko Maejima,* Masanori Nakata,* Katsuya Dezaki, Putra Santoso, Yifei Yang, Takeshi Arai, Darambazar Gantulga, Shinji Muroya, Alan K. Lefor, Masafumi Kakei, Eiju Watanabe, and Toshihiko Yada Department of Physiology, Division of Integrative Physiology, Jichi Medical University School of Medicine, Shimotsuke, Tochigi, Japan;(More)
Arcuate Na+,K+-ATPase senses systemic energy states and regulates feeding 1 behavior through glucose-inhibited neurons 2 3 Hideharu Kurita, Kai Y. Xu, Yuko Maejima, Masanori Nakata, Katsuya Dezaki, Putra 4 Santoso, Yifei Yang, Takeshi Arai, Darambazar Gantulga, Shinji Muroya, Alan K. Lefor, 5 Masafumi Kakei, Eiju Watanabe, Toshihiko Yada* 6 7 Department of(More)
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