Highly Influential Citations17
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BDNF and its associated tropomyosin-related kinase receptor B (TrkB) nurture vessels and nerves serving the heart. However, the direct effect of BDNF/TrkB signaling on the myocardium is poorly… Continue Reading
Brugada syndrome is a rare cardiac arrhythmia disorder, causally related to SCN5A mutations in around 20% of cases. Through a genome-wide association study of 312 individuals with Brugada syndrome… Continue Reading
SCN5A is abundant in heart and has a major role in INa. Loss-of-function mutation in SCN5A results in Brugada syndrome (BrS), which causes sudden death in adults. It remains unclear why disease… Continue Reading
RATIONALE Cardiac resynchronization therapy (CRT) is an established treatment for patients with chronic heart failure. However, CRT-associated structural and functional remodeling at cellular and… Continue Reading
Background: Optimal left ventricular (LV) site selection is major clinical interest for cardiac resynchronization therapy (CRT) implantation. The impact of LV lead position on outcome in CRT patients… Continue Reading
AIMS Long QT syndrome (LQTS) is an inheritable and life-threatening disease; however, it is often difficult to determine disease characteristics in sporadic cases with novel mutations, and more… Continue Reading
Tasha E Fingerlin, Elissa Murphy, Weiming Zhang, Anna L Peljto, Kevin K Brown, Mark P Steele, James E Loyd, Gregory P Cosgrove, David Lynch, Steve Groshong, Harold R Collard, Paul J Wolters,… Continue Reading
Background: Congenital long QT syndrome (LQTS) is a monogenic predisposition to lethal cardiac arrhythmias.Despite decades of investigation and discovery of multiple responsible genes, a molecular ...