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Yeast Cdk1 translocates to the plus end of cytoplasmic microtubules to regulate bud cortex interactions
The budding yeast spindle aligns along the mother–bud axis through interactions between cytoplasmic microtubules (CMs) and the cell cortex. Kar9, in complex with the EB1‐related protein Bim1,… Expand
The XMAP215 homologue Stu2 at yeast spindle pole bodies regulates microtubule dynamics and anchorage
- Takeo Usui, H. Maekawa, Gislene Pereira, E. Schiebel
- Biology, Medicine
- The EMBO journal
- 15 September 2003
The yeast protein Stu2 belongs to the XMAP215 family of conserved microtubule‐binding proteins which regulate microtubule plus end dynamics. XMAP215‐related proteins also bind to centrosomes and… Expand
A novel action of terpendole E on the motor activity of mitotic Kinesin Eg5.
To reveal the mechanism of mitosis, the development of M phase-specific inhibitors is an important strategy. We have been screening microbial products to find specific M phase inhibitors that do not… Expand
Identification of a strong binding site for kinesin on the microtubule using mutant analysis of tubulin
The kinesin‐binding site on the microtubule has not been identified because of the technical difficulties involved in the mutant analyses of tubulin. Exploiting the budding yeast expression system,… Expand
The Anticancer Natural Product Pironetin Selectively Targets Lys352 of α-Tubulin
Abstract Pironetin is a potent inhibitor of tubulin assembly and arrests cell cycle progression in M phase. Analyses of its structure-activity relationships suggested that pironetin covalently binds… Expand
Garbled messages and corrupted translations.
- Tilman Schneider-Poetsch, Takeo Usui, D. Kaida, M. Yoshida
- Biology, Medicine
- Nature chemical biology
- 1 March 2010
Following transcription, genomic information begins a long journey toward translation of its nucleotide sequence into the amino acids of a protein. In eukaryotes, synthesized pre-mRNAs become… Expand
Discovery of Natural Products Possessing Selective Eukaryotic Readthrough Activity: 3‐epi‐Deoxynegamycin and Its Leucine Adduct
Herein we report the first discovery of natural readthrough products that do not display antimicrobial activity. Two natural negamycins, 3‐epi‐deoxynegamycin and its leucine adduct, isolated 37 years… Expand
Studies on inhibitory mechanism of microtubule inhibitors
Microtubules are key components of the cytoskeleton of eukaryotic cells and play important roles in many aspects of biological functions. Development of microtubule inhibitors, which interfere with… Expand
Multidrug Sensitive Yeast Strains, Useful Tools for Chemical Genetics
The budding yeast Saccharomyces cerevisiae is a useful eukaryote model organism for application to chemical biology studies, for example, drug screening, drug evaluation, and target identification.… Expand
Fungal Metabolite, Epoxyquinol B, Crosslinks Proteins by Epoxy-Thiol Conjugation.