Takeo Asakawa

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A 5th generation SPARC64 processor is fabricated in 130nm SOI CMOS process with 8 layers of Cu metallization. It runs at 1.3GHz with 34.7W power dissipation in the laboratory. The chip contains over 190M transistors with 19M in logic circuits. The chip size is 18.14mm x 15.99mm. The error detection and recovery mechanism is implemented for execution units(More)
We developed a 1.3-GHz SPARC-V9 processor: the SPARC64 V. This processor is designed to address requirements for enterprise servers and high-performance computing. Processing speed under multi-user interactive workloads is very sensitive to system balance because of the large number of memory requests included. From many years of experience with such(More)
Effects of nitroglycerin (3 micrograms/kg/min i.v.) on regional myocardial contractility during acute coronary stenosis were studied in open-chest dogs using a strain-gauge arch. Stenosis-induced stepwise decreases in coronary perfusion pressure (CPP) at less than 40 mm Hg correspondingly reduced contractility in the underperfused area and increased the(More)
A GTP-dependent regulatory component of adenylate cyclase was found in myelin from rat brain. The fraction solubilized from myelin contained a component that reconstituted guanine nucleotide-responsive adenylate cyclase activity when combined with the catalytic unit of adenylate cyclase prepared from rat brain. Purified myelin demonstrated little adenylate(More)
Cholera toxin ADP-ribosylates four types of myelin basic proteins (MBPs) of Mr 14,000, 17,500, 19,000 and 22,000 in rat brain myelin. On an analysis by sodium dodecyl sulfate-polyacrylamide gel electrophoresis, MBP underwent mono- and multi-(ADP-ribosyl)ation by cholera toxin and thus modified MBP migrated on the gel as several discrete protein bands, the(More)
Accurate determination of low levels of protein in samples containing large amounts of interfering substances is rather difficult. Precipitation-bicinchoninic acid (BCA) assay as reported can concentrate and partially decontaminate the protein by adding sodium deoxycholate (DOC) and trichloroacetic acid (TCA) to the sample. Yet, this procedure alone has(More)
Correlation between hemodynamic changes and plasma catecholamines or renin activity were studied in dogs anesthetized with pentobarbital, 30 mg/kg, i.v. Pentobarbital increased heart rate in all cases regardless of changes in plasma catecholamines, and the increase was not depressed fully by propranolol. Blood pressure (BP) showed a transient decline just(More)
ATP/dithiothreitol (DTT)-stimulated guanylate cyclase (GC) in lung membrane was stimulated 18-fold by ATP and DTT, and both its activity and atrial natriuretic peptide (ANP)-stimulated GC activity were observed to be additive. ATP/DTT-stimulated GC was solubilized by octyl glucoside (OG) to examine the mechanism of ATP/DTT-stimulation. GC in OG-extracts was(More)