Takefumi Hiraga

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Serotonin (5HT) plays major roles in the physiological regulation of many behavioral processes, including sleep, feeding, and mood, but the genetic mechanisms by which serotonergic neurons arise during development are poorly understood. In the present study, we have investigated the development of serotonergic neurons in the zebrafish. Neurons exhibiting(More)
Neurotoxic effects of 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD) has not been fully elucidated, despite the known potent agonist of arylhydrocarbon receptor (AhR), which activation induces cytochrome P450 1A and several representative toxicities of halogenated aromatic hydrocarbons. In the present study, the effects of TCDD on cell death in zebrafish(More)
This paper presents the low power architecture and design techniques for the mobile handset LSI Medity<sup>TM</sup> M2. M2 is a second-generation mobile handset LSI which integrates a digital baseband and application processor on a chip. M2 is capable of supporting 3.2 Mbps HSDPA, WCDMA communications, and rich, high-resolution multimedia applications,(More)
Bisphosphonate (BP), a specific inhibitor of osteoclasts, has been widely used as a beneficial agent for the treatment of bone metastases in patients with breast cancer. It is well recognized that BP reduces osteolysis by promoting apoptosis in osteoclasts. However, recent animal and human data suggest that BPs not only reduce osteolysis associated with(More)
Tumor-reactive T cells, known as tumor-infiltrating lymphocyte(TIL)s are known to infiltrate various tumors. Although TILs exert cytotoxic activities against tumor cells, only a small percentage of tumors usually contain TILs that specifically react to tumor antigens. Because the exact role of these lymphocytes is unclear, we investigated the mechanisms of(More)
This paper presents the low power architecture and design techniques for the mobile handset LSI Medity#8482; M2. M2 is a second-generation mobile handset LSI which integrates a Digital baseband and Application processor on a chip. M2 is capable of supporting 3.2 Mbps HSDPA, WCDMA communications, and rich, high-resolution multimedia applications, while power(More)
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