Takayuki Yokoyama

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Expressed emotion (EE) is the attitude of criticism and emotional overinvolvement of a key relative toward a patient, and is one of the family factors that contribute to the course of psychiatric illness. The relationship between EE and 6-month outcome in 40 outpatients with major depression was investigated in this study. In the nonremission group (n = 17,(More)
Ectopic fat accumulation plays important roles in various metabolic disorders and cardiovascular diseases. Recent studies reported that myocardial triglyceride (TG) content measured by proton magnetic resonance spectroscopy ((1)H-MRS) is associated with aging, diabetes mellitus, and cardiac dysfunction. However, myocardial TG content in athletes has not yet(More)
Proton magnetic resonance spectroscopy (1H-MRS) enables the assessment of myocardial triglyceride (TG) content, which is reported to be associated with cardiac dysfunction and morphology accompanied by metabolic disorder and cardiac hemodynamic status. The clinical usefulness of myocardial TG content measurements in patients with left ventricular(More)
Based on randomized controlled trials conducted in western countries, we proposed a pharmacotherapy algorithm for DSM-IV dysthymia in Japan. The main strategy of the algorithm are: firstly, one of the antidepressants is selected for an initial agent, and secondly, efficacy of the selected antidepressant is evaluated at 8 to 12 weeks. The agent with(More)
Expressed emotion (EE) has been shown in various countries to be a good predictor of the clinical course of a patient's mental illness. Because the traditional EE interview requires considerable time and effort, this study examined the reliability of a method called the five-minute speech sample (FMSS) for assessing EE. The samples of 65 subjects were rated(More)
We have developed a radioreceptor binding assay (RRA) method for melatonin using membranes from Chinese hamster ovary cells that can stably express human mel-1a receptors. We measured melatonin levels in plasma samples collected every 4h for 24h using the RRA and radioimmunoassay (RIA) methods, simultaneously. There was a statistically significant(More)
We investigated the relationship between 9-month relapse of 40 outpatients with schizophrenia and expressed emotion (EE) evaluated by the Five-Minute Speech Sample (FMSS). The results of this study suggest that the FMSS is suitable for use as a convenient instrument to measure EE, although it shows more false-positive results. Therefore borderline EE of the(More)
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