Osteoclasts are derived from hematopoietic precursor cells belonging to the monocyte/macrophage lineage. Osteoclast development has been reported to be regulated by several molecules such as macrophage colony-stimulating factor (M-CSF), receptor activator of nuclear factor (NF)-kappaB ligand (RANKL), and a decoy receptor of RANKL, osteoprotegerin (OPG).… (More)
It has long been a practical problem for surgical pathologists to distinguish mesothelium from epithelium in order to make a positive diagnosis of mesothelioma. In this study, we developed a new monoclonal antibody, designated MS-2761 (IgG1, k), against cultured non-neoplastic mesothelial cells. Immunohistochemistry and slot-blot analysis revealed that this… (More)
An autotuning method for the optimum sigmoid function of neural networks is proposed. It is based on the steepest descent method. Simulated results using a learning-type direct controller confirm both the practicality and the characteristics of the autotuning method.
Malignant ascites from pancreatic cancer patients has been reported to stimulate migration of pancreatic cancer cells through lysophosphatidic acid (LPA) and LPA(1) receptors. Indeed, ascites- and LPA-induced migration was inhibited by Ki16425, an LPA(1) and LPA(3) antagonist, in Panc-1 cells. Unexpectedly, however, in the presence of Ki16425, ascites and… (More)
A method is proposed for preventing privacy invasion through unintentional capture of facial images. Prevention methods such as covering the face and painting particular patterns on the face are effective but hinder face-to-face communication. The proposed method overcomes this problem through the use of a device worn on the face that transmits… (More)
Keywords: Topology optimization Finite element method Level set method Phase field method Tikhonov regularization method a b s t r a c t This paper proposes a new topology optimization method, which can adjust the geometrical complexity of optimal configurations, using the level set method and incorporating a fictitious interface energy derived from the… (More)