Takayuki Nagae

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Hydrostatic pressure induces structural changes in proteins, including denaturation, the mechanism of which has been attributed to water penetration into the protein interior. In this study, structures of 3-isopropylmalate dehydrogenase (IPMDH) from Shewanella oneidensis MR-1 were determined at about 2 Å resolution under pressures ranging from 0.1 to 650(More)
The main idea of the HypHI project is to perform precise hypernuclear spectroscopy with stable and unstable heavy ion beam at GSI and FAIR[1]. The HypHI collaboration plans the first experiment Phase 0 in 2009 to investigate the feasibility of hypernuclear spectroscopy with heavy ion beams. In the Phase 0 experiment, three sets of Scintillating Fiber(More)
The protein crystallography beamline BL2S1, constructed at one of the 5 T superconducting bending-magnet ports of the Aichi synchrotron, is available to users associated with academic and industrial organizations. The beamline is mainly intended for use in X-ray diffraction measurements of single-crystals of macromolecules such as proteins and nucleic(More)
Visit-to-visit blood pressure (BP) variability is an important predictor of stroke. However, which antihypertensive drug combination is better at reducing visit-to-visit BP variability and therefore at reducing stroke incidence remains uncertain. We have previously reported that the dihydropyridine calcium channel blocker benidipine combined with a(More)
3-Isopropylmalate dehydrogenase (IPMDH) from the extreme piezophile Shewanella benthica (SbIPMDH) is more pressure-tolerant than that from the atmospheric pressure-adapted Shewanella oneidensis (SoIPMDH). To understand the molecular mechanisms of this pressure tolerance, we analyzed mutated enzymes. The results indicate that only a single mutation at(More)
Crystal structures of hen egg-white lysozyme (HEWL) determined under pressures ranging from ambient pressure to 950 MPa are presented. From 0.1 to 710 MPa, the molecular and internal cavity volumes are monotonically compressed. However, from 710 to 890 MPa the internal cavity volume remains almost constant. Moreover, as the pressure increases to 950 MPa,(More)
Neutral-pion π(0) spectra were measured at midrapidity (|y|<0.35) in Au+Au collisions at √(s(NN))=39 and 62.4 GeV and compared with earlier measurements at 200 GeV in a transverse-momentum range of 1<p(T)<10 GeV/c. The high-p(T) tail is well described by a power law in all cases, and the powers decrease significantly with decreasing center-of-mass energy.(More)
We have measured the branching ratio of the three-body process in the nonmesonic weak decay of Lambda12C to be 0.29+/-0.13. This result was obtained by reproducing the nucleon and the nucleon pair yields introducing a measured final state interaction. At the same time, we have determined the absolute decay widths, Gamma(n) and Gamma(p), along with Gamma2N,(More)
The HypHI collaboration prepares currently for the precise hypernuclear spectroscopy with stable heavy ion beams and rare isotope beams at GSI and FAIR in order to enable studies of structures of hypernuclei at extreme isospin and direct measurements of hypernuclear magnetic moments for the first time [1]. The first step of the HypHI project is so called(More)
The Phase 0 experiment of the HypHI project [1] planned in September 2009 at GSI is devoted to demonstrate the feasibility of a precise hypernuclear spectroscopy by using heavy ion collisions. In the experiment, we will concentrate on studying light hypernuclei such as 3 Λ H, 4 Λ H and 5 Λ He produced by collisions of a 6 Li and a 12 C beam at 2 A GeV with(More)