Takayuki Igarashi

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Primary erythermalgia is a rare neuropathy characterized by attacks of burning pain and redness in the extremities in response to warm stimuli. We describe here a boy with erythermalgia whose painful attacks began in infancy. We found a novel mutation of SCN9A, which is a responsible gene for primary erythermalgia in this case. In his teens, he developed(More)
Secretory leukoprotease inhibitor (SLPI) protects tissue against the destructive action of neutrophil elastase at the site of inflammation. Recent studies on new functions of SLPI have demonstrated that SLPI may play a larger role in innate immunity than merely as a protease inhibitor. To clarify the functions of SLPI in bacterial infections, we generated(More)
STUDY DESIGN An experimental study to clarify the effects of nucleus pulposus on blood flow in the dorsal root ganglion and hindpaws. OBJECTIVES To investigate the effects of application of nucleus pulposus to nerve root on blood flow in the dorsal root ganglion and the corresponding hindpaw. SUMMARY OF BACKGROUND DATA It has been reported(More)
To study the pathogenesis of the central nervous system (CNS) involvement associated with verocytotoxin-producing Escherichia coli infection, we developed an animal model by administering verocytotoxin 2 to rabbits either intravenously or intrathecally. After an interval of 2-9 days, the rabbits became paralyzed in a dose-dependent manner and in the absence(More)
In order to investigate long-term effects of indwelling urinary catheters on renal functions, in 46 patients (27 male and 19 female) with ureterostomy or nephrostomy serum creatinine values were measured periodically. Average age of the patients was 60.6 years old. Duration of catheterization was more than 3 years (average 8.1 years). Renal dysfunction was(More)
Considerable literature (1-6) is available on "the cumulative effect of digitalis", but the mechanism involved in the appearance of this "cumulative effect" is still a matter of speculation. Previous reports suggest the possibility that cardiac glycosides may produce their effects on the heart through the central nervous system (CNS) (7, 8). The present(More)
We report here the results of a dose evaluation based on information obtained in a 2011 questionnaire as compared with an investigation made in 2007. Briefly, in general radiography, the dose used in most examinations in 2011 was lower than in 2007. However, since the entrance surface dose for chest X-rays showed an increase, there is a need to standardize(More)
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