Takayoshi Otsuka

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DNA methylation is a fundamental epigenetic modification in vertebrate genomes and a small fraction of genomic regions is hypomethylated. Previous studies have implicated hypomethylated regions in gene regulation, but their functions in vertebrate development remain elusive. To address this issue, we generated epigenomic profiles that include(More)
The Ashtekar-Mason-Newman equations are used to construct the hyperkähler metrics on four dimensional manifolds. These equations are closely related to anti self-dual Yang-Mills equations of the infinite dimensional gauge Lie algebras of all volume preserving vector fields. Several examples of hyperkähler metrics are presented through the reductions of anti(More)
To address conserved and unique features of fish pancreas development, we performed extensive analyses of pancreatic development in medaka embryos and adults using pdx1- and ptf1a-transgenic medaka, in situ hybridization and immunohistochemistry. The markers used in these analyses included pdx1, nkx6.1, nkx6.2, nkx2.2, Islet1, insulin, Somatostatin,(More)
Recent advances in genomics and gene editing have expanded the range of model organisms to include those with interesting biological capabilities such as regeneration. Among these are the classic models of regeneration biology, the salamander. Although stimulating endogenous regeneration in humans likely is many years away, with advances in stem cell(More)
The pancreas plays important roles in the regulation of blood glucose, and is a well-studied organ in mammals because its dysfunction causes serious disorders, such as diabetes mellitus. However, mammals have the limited capacity for tissue regeneration in their organs, including pancreas. Fish may be an attractive model for regeneration studies, as fish(More)
DNAmethylation is a fundamental epigeneticmodification in vertebrate genomes and a small fraction of genomic regions is hypomethylated. Previous studies have implicated hypomethylated regions in gene regulation, but their functions in vertebrate development remain elusive. To address this issue, we generated epigenomic profiles that include base-resolution(More)
The Ashtekar-Mason-Newman equations are used to construct the hyperkähler metrics on four dimensional manifolds. These equations are closely related to anti self-dual Yang-Mills equations of the infinite dimensional gauge Lie algebras of all volume preserving vector fields. Several examples of hyperkähler metrics are presented through the reductions of anti(More)
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