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DNAJB6 myopathy in an Asian cohort and cytoplasmic/nuclear inclusions
TLDR
The immunohistochemical analysis detected cytoplasmic accumulations associated with chaperone-assisted selective autophagy together with intranuclear accumulations of DNAJB6 and heat shock 22-kD protein 8 (HSPB8) and this is the first report of Asian patients with LGMD1D.
Inclusion complexation of triton X-100 with α-, β- and γ-cyclodextrins
Abstract Inclusion complexes of Triton X-100 (TX-100) with α-, β- and γ-cyclodextrins (α-, β- and γ-CD) in water were investigated by the surface tension method, circular dichroism, 1 H NMR
Effects of erythropoietin on angiogenesis after myocardial infarction in porcine
TLDR
Erythropoietin accelerates angiogenesis via the upregulation of systemic levels such as HGF and FGF, and the local expression of VEGF and IGF, in porcine MI.
Close monitoring of initial enzyme replacement therapy in a patient with childhood-onset Pompe disease
TLDR
Close monitoring of initial ERT is reported, focusing especially on the first year, in a 12-year-old boy with childhood-onset Pompe disease, finding that the timed test results corresponded better to his changing clinical course than did grip power, MMT or 6-min walking test results.
Histomorphometric study of trabecular channels in normal iliac bone
TLDR
Cancellous bone channels in the normal iliac crest have been studied histologically and by histomorphometry, and it is improbable that they make a significant contribution to bone remodeling, but it is probable that they aid the intraosseous microcirculation and mineral exchange in thick trabecula and bifurcations, where they are mainly located.
Efficacy of primary treatment with immunoglobulin plus ciclosporin for prevention of coronary artery abnormalities in patients with Kawasaki disease predicted to be at increased risk of non-response
TLDR
Combined primary therapy with IVIG and ciclosporin was safe and effective for favourable coronary artery outcomes in Kawasaki disease patients who were predicted to be unresponsive to IVIG.
Small LDL-cholesterol is superior to LDL-cholesterol for determining severe coronary atherosclerosis.
TLDR
Multivariate logistic regression analysis revealed that sd-LDL-C levels were significantly associated with severe CHD independently of LDL-C, and are more powerful for the determination of severe stable CHD.
Eplerenone suppresses neointimal formation after coronary stent implantation in swine.
TLDR
Orally administered eplerenone attenuated collagen accumulation within the neointima, thereby inhibiting neointimal hyperplasia after stent implantation in swine.
Coronary vein infusion of multipotent stromal cells from bone marrow preserves cardiac function in swine ischemic cardiomyopathy via enhanced neovascularization
TLDR
MSC infusion via the coronary vein prevented the progression of cardiac dysfunction in chronic MI, and this favorable effect appeared to derive not from cell differentiation, but from enhanced neovascularization by angiogenic factors secreted from the MSCs.
Time-course of changes in the levels of interleukin 6 in acutely decompensated heart failure.
TLDR
IL-6 levels possibly reflect the severity of heart failure and thus may be useful for the evaluation of disease status in acutely decompensated heart failure.
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