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IRAK-4-dependent degradation of IRAK-1 is a negative feedback signal for TLR-mediated NF-kappaB activation.
- Miho Kubo-Murai, K. Hazeki, K. Nigorikawa, Takatoshi Omoto, N. Inoue, O. Hazeki
- Biology, Medicine
- Journal of biochemistry
- 13 December 2007
The activation of interleukin 1 receptor-associated kinase (IRAK)-1 is a key event in the transmission of signals from Toll-like receptors (TLRs). The catalytic activity of the protein kinase is not… Expand