Takasi Masuyama

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The mechanism of L-DOPA for antinociception was investigated. Nociceptive behaviors in mice after an intrathecal (i.t.) administration of substance P were evaluated. L-DOPA (i.t.) dose-dependently attenuated the substance P-induced nociceptive behaviors. Co-administration of benserazide (i.t.), a DOPA decarboxylase inhibitor, abolished the antinociceptive(More)
BACKGROUND It was recently reported that isoflurane increases dopamine release in the striatum in rats both in vivo and in vitro, and that isoflurane inhibits uptake of dopamine in the rat brain synaptosomes. However, the functional role of these effects of isoflurane on dopamine neurons is uncertain. Dopaminergic mechanisms within the nucleus accumbens and(More)
Substance P (SP) has previously been shown to be involved in the transmission of nociceptive information in the spinal dorsal horn. In this study we investigated whether a functional interaction exists between SP and excitatory amino acids in the spinal cord of mice. Behavioral responses were observed after intrathecal co-administration of SP and(More)
The functional interaction between substance P (SP) and N-methyl-D-aspartate (NMDA) was studied to clarify the diversity of the roles of SP in nociceptive processes at the spinal level in mice. Behavioral responses elicited by intrathecal co-administration of NMDA (0.25 nmol) with various doses of SP (0.3-12 pmol) were observed for 1 min. The high dose of(More)
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