Haemagglutinin mutations responsible for the binding of H5N1 influenza A viruses to human-type receptors
It is shown that some H5N1 viruses isolated from humans can bind to both human and avian receptors, in contrast to those isolated from chickens and ducks, which recognize the avian receptor exclusively.
Avian flu: Isolation of drug-resistant H5N1 virus
The isolation of an H5N1 virus from a Vietnamese girl that is resistant to the drug oseltamivir, which is an inhibitor of the viral enzyme neuraminidase and is currently used for protection against and treatment of influenza is reported.
Sialic Acid Species as a Determinant of the Host Range of Influenza A Viruses
ABSTRACT The distribution of sialic acid (SA) species varies among animal species, but the biological role of this variation is largely unknown. Influenza viruses differ in their ability to recognize…
Role of sulfatide in normal and pathological cells and tissues
The important biological roles of sulfatide in the nervous system, insulin secretion, immune system, hemostasis/thrombosis, cancer, and microbial infections including human immunodeficiency virus and influenza A virus are discussed.
Enhanced virulence of influenza A viruses with the haemagglutinin of the 1918 pandemic virus
It is demonstrated that the HA of the 1918 virus confers enhanced pathogenicity in mice to recent human viruses that are otherwise non-pathogenic in this host.
Recognition of N-Glycolylneuraminic Acid Linked to Galactose by the α2,3 Linkage Is Associated with Intestinal Replication of Influenza A Virus in Ducks
The results suggest that recognition of the NeuGcα2,3-Gal moiety plays an important role in the enterotropism of avian influenza viruses.
Influenza A (H5N1) Viruses from Pigs, Indonesia
Pigs may serve as intermediate hosts in which this avian virus can adapt to mammals, according to the TOC summary.
Oligosaccharides as Receptors for JC Virus
The results suggest that the oligosaccharides of glycoproteins and glycolipids work as JCV receptors and may be feasible as anti-JCV agents.
Structure and anti-dengue virus activity of sulfated polysaccharide from a marine alga.
Receptor Specificities of Human Respiroviruses
The abilities of human parainfluenza virus types 1 and 3 to bind to different types of gangliosides are evaluated, indicating that the molecular species of glycoconjugate that hPIV-1 recognizes are more limited than those recognized by hPiv-3.