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- Futoshi Higa, Morikazu Akamine, +6 authors Jiro Fujita
- The Journal of antimicrobial chemotherapy
- 2005

OBJECTIVES
The activities of pazufloxacin and tosufloxacin against Legionella spp. were evaluated in vitro and compared with those of other quinolones, macrolides and azithromycin.
METHODS
The conventional MICs were determined by the microbroth dilution method. Intracellular activities of drugs were evaluated by a cfu count. The minimal extracellular… (More)

- Paul H Edelstein, Baofeng Hu, Takashi Shinzato, Martha A C Edelstein, Wenlian Xu, Maurice J Bessman
- Infection and immunity
- 2005

We studied the identity and function of the 528-bp gene immediately upstream of Legionella pneumophila F2310 ptsP (enzyme I(Ntr)). This gene, nudA, encoded for a Nudix hydrolase based on the inferred protein sequence. NudA had hydrolytic activity typical of other Nudix hydrolases, such as Escherichia coli YgdP, in that Ap(n)A's, in particular diadenosine… (More)

- Takashi Shinzato, Alejandro Raul Hernandez Montoya
- PloS one
- 2015

In portfolio optimization problems, the minimum expected investment risk is not always smaller than the expected minimal investment risk. That is, using a well-known approach from operations research, it is possible to derive a strategy that minimizes the expected investment risk, but this strategy does not always result in the best rate of return on… (More)

- Takashi Shinzato, Muneki Yasuda
- PloS one
- 2015

The typical behavior of optimal solutions to portfolio optimization problems with absolute deviation and expected shortfall models using replica analysis was pioneeringly estimated by S. Ciliberti et al. [Eur. Phys. B. 57, 175 (2007)]; however, they have not yet developed an approximate derivation method for finding the optimal portfolio with respect to a… (More)

New megastigmane (1) and tetraketide (2) were isolated from the leaves of Euscaphis japonica and the structures were elucidated by means of spectroscopic and chemical evidence.

- H Otsuka, X N Zhong, E Hirata, T Shinzato, Y Takeda
- Chemical & pharmaceutical bulletin
- 2001

Eight megastigmane glycosides were isolated from the leaves of Myrsine seguinii collected in Okinawa. Three of them were found to be known compounds, i.e., ampelopsisionoside, alangionoside J, and linarionoside A. The structures of the new megastigmane glycosides were elucidated from the spectroscopic data and their absolute stereochemistries were… (More)

- Takashi Shinzato
- ArXiv
- 2016

We discuss replica analytic continuation using several simple models in order to prove mathematically the validity of replica analysis, which is used in a wide range of fields related to large scale complex systems. While replica analysis consists of two analytical techniques, the replica trick (or replica analytic continuation) and the thermodynamical… (More)

—Price of anarchy, the performance ratio, which could characterize the loss of efficiency of the distributed supply chain management compared with the integrated supply chain management is discussed by utilizing newsvendor problem in single period which is well-known. In particular, some of remarkable distributed policies are handled, the performance ratios… (More)

Learning behavior of simple perceptrons is analyzed for a teacher-student scenario in which output labels are provided by a teacher network for a set of possibly correlated input patterns, and such that teacher and student networks are of the same type. Our main concern is the effect of statistical correlations among the input patterns on learning… (More)

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