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Transcriptional induction of mammalian ER quality control proteins is mediated by single or combined action of ATF6alpha and XBP1.
Suppressive function of androgen receptor in bone resorption
- H. Kawano, Takashi R. Sato, S. Kato
- Biology, MedicineProceedings of the National Academy of Sciences…
- 18 July 2003
It is shown that inactivation of AR in mice using a Cre-loxP system-mediated gene-targeting technique caused bone loss in males but not in females, and results indicate that AR function is indispensable for male-type bone formation and remodeling.
The Rab8 GTPase regulates apical protein localization in intestinal cells
It is found that apical peptidases and transporters localized to lysosomes in the small intestine of Rab8-deficient mice, and this led to a marked reduction in the absorption rate of nutrients in theSmall intestine, and ultimately to death.
Premature ovarian failure in androgen receptor-deficient mice.
- Hiroko Shiina, Takahiro Matsumoto, S. Kato
- BiologyProceedings of the National Academy of Sciences…
- 3 January 2006
It is suggested that AR function is required for normal female reproduction, particularly folliculogenesis, and that AR is a potential therapeutic target in POF syndrome.
TDAG8 Is a Proton-sensing and Psychosine-sensitive G-protein-coupled Receptor*
T cell death-associated gene 8 is one of the proton-sensing GPCRs coupling to adenylyl cyclase and psychosine, and its related lysosphingolipids behave as if they were antagonists against protein-s sensing receptors, including TDAG8, GPR4, and OGR1.
Brain masculinization requires androgen receptor function.
- Takashi R. Sato, Takahiro Matsumoto, S. Kato
- Biology, PsychologyProceedings of the National Academy of Sciences…
- 10 February 2004
It is suggested that perinatal brain masculinization requires AR function and that expression of male-typical behaviors in adults is mediated by both AR-dependent and -independent androgen signaling.
Harmonin Mutations Cause Mechanotransduction Defects in Cochlear Hair Cells
Induction of Liver Steatosis and Lipid Droplet Formation in ATF6α-Knockout Mice Burdened with Pharmacological Endoplasmic Reticulum Stress
- Keisuke Yamamoto, Kazuna Takahara, K. Mori
- Biology, MedicineMolecular biology of the cell
- 1 September 2010
We burdened mice with intraperitoneal injection of the endoplasmic reticulum stress-inducing reagent tunicamycin, and found that wild-type mice were able to recover from the insult, whereas…
Vesicular and non-vesicular transport feed distinct glycosylation pathways in the Golgi
The results indicate that the transport modality across the Golgi complex is a key determinant for the glycosylation pattern of a cargo and establish a new paradigm for the branching of the glycosphingolipid synthetic pathway.
Rab8a and Rab8b are essential for several apical transport pathways but insufficient for ciliogenesis
The results highlight the compensatory effect of Rab8a and Rab8b in apical transport, and the complexity of theApical transport process, whereas additional loss of Rab10 greatly affects ciliogenesis.