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We report a method of femtosecond crystallography for solving radiation damage-free crystal structures of large proteins at sub-angstrom spatial resolution, using a large single crystal and the femtosecond pulses of an X-ray free-electron laser (XFEL). We demonstrated the performance of the method by determining a 1.9-Å radiation damage-free structure of(More)
— This paper describes software system for a hu-manoid robot viewed from a motion generation aspect by taking kitchen helping behaviors as an example of a real world task. Our software consists of high level reasoning modules including 3D geometric model based action/motion planner and runtime modules contains 3D visual processor, force manipulation(More)
— This paper describes design and development of system software for humanoid robots that researchers who specialized in not only biped walking but also various field are able to use humanoid robots as a research tool. For this purpose, the system for humanoid must integrate and organize each subsystems such as control, recognition, dialogue, planning and(More)
INTRODUCTION Polymyositis (PM) and dermatomyositis (DM) are chronic inflammatory muscle diseases, in which chemokines are thought to contribute to inflammatory cell migration into muscle. In this study, we retrospectively analyzed the expressions of CX3CL1/fractalkine and its corresponding receptor, CX3CR1, in muscle and lung with interstitial lung disease(More)
BACKGROUND Our phase III clinical trial of pirfenidone for patients with idiopathic pulmonary fibrosis (IPF) revealed the efficacy in reducing the decline of vital capacity (VC) and increasing the progression-free survival (PFS) time by pirfenidone. Recently, marginal decline in forced VC (FVC) has been reported to be associated with poor outcome in IPF. We(More)
BACKGROUND A phase III trial in Japan showed that pirfenidone is effective for idiopathic pulmonary fibrosis (IPF). To find out which patients specifically benefit from pirfenidone, we analyzed in an exploratory manner the data from the phase III trial. METHODS The patients in the phase III trial were stratified by baseline percentage predicted vital(More)
BACKGROUND Patients with idiopathic interstitial pneumonias sometimes have a few features of connective tissue disease (CTD) and yet do not fulfil the diagnostic criteria for any specific CTD. OBJECTIVE This study was conducted to elucidate the characteristics, prognosis, and disease behavior in patients with interstitial lung disease (ILD) associated(More)
— This paper proposes the new robot programming environment in which robot motion programming environment and dynamics simulator are integrated. This allows robot motion programs to include simulation descriptions. Additionally, a new implementation of simulation that is composed by simulation modules is presented, on the other hand, conventional simulators(More)