Takashi Nishizaki

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BACKGROUND Phase I/II clinical trials of S-1 plus cisplatin for advanced gastric cancer have yielded good responses and the treatment was well tolerated. In this S-1 Plus cisplatin versus S-1 In RCT In the Treatment for Stomach cancer (SPIRITS) trial, we aimed to verify that overall survival was better in patients with advanced gastric cancer treated with(More)
OBJECTIVE To evaluate the recent results of liver resection in patients with hepatocellular carcinoma. DESIGN Retrospective study. SETTING A university hospital in Japan. PATIENTS Two hundred eighty patients who underwent liver resection with complete extirpation of hepatocellular carcinoma from 1985 to 1993. MAIN OUTCOME MEASURES Morbidity and(More)
OBJECTIVE To estimate the effectiveness of hepatic resection on hepatocellular carcinoma (HCC) in the elderly. DESIGN Comparison with younger patients. SETTING A municipal hospital and a large university hospital in Japan. PATIENTS The study included 39 patients (age > or = 70 years [the elderly group]) and 229 patients (age < 70 years [the younger(More)
BACKGROUND & AIMS Little has been addressed on the characteristics and prognostic factors of recurrent hepatocellular carcinoma after undergoing a hepatic resection for primary hepatocellular carcinoma. The aim of this study was to clarify the aforementioned matters of recurrent hepatocellular carcinoma. METHODS One hundred fifty-nine patients with(More)
To assess the differences in the surgical results between patients with hepatitis B- and hepatitis C-related hepatocellular carcinoma (HCC), the operative outcomes of 30 patients with hepatitis B surface antigen (HBsAg)-positive (the B-HCC group) and 96 patients with hepatitis C antibody (HCVAb)-positive (the C-HCC group), who had undergone hepatic(More)
OBJECTIVES This study was conducted to clarify the characteristics of patients with extrahepatic primary cancers (EHPC) associated with hepatocellular carcinoma (HCC), as well as to investigate the influence of EHPC on both patient survival and disease-free survival after hepatic resection. METHODS Forty-one of 463 patients who underwent hepatic resection(More)
Recent experimental studies have shown that Bcl-2, which has been established as a key player in the control of apoptosis, plays a role in regulating the cell cycle and proliferation. The aim of this study was to investigate the relationship between Bcl-2 and p27 protein expression, p53 protein expression and the proliferation activity as defined by the(More)
BACKGROUND Postoperative pancreatic fistula (POPF) remains a major complication after pancreaticoduodenectomy (PD), and the prognosis of patients with pancreatic ductal adenocarcinoma (PDAC) after PD is poor. PATIENTS AND METHODS A multi-institutional retrospective study was performed in 174 patients who underwent PD for PDAC from 2007 to 2012. The(More)
BACKGROUND The clinical significance of changes in serum human hepatocyte growth factor (hHGF) in patients having hepatectomy remains unclear, partly because of various perioperative factors, such as underlying diseases and surgical procedures. STUDY DESIGN Human hepatocyte growth factor was measured preoperatively and then on postoperative days 1, 3, 5,(More)
BACKGROUND The number of liver transplant recipients is increasing but donor organ shortages have become more severe. The effect of milrinone, a type 3 phosphodiesterase inhibitor (PDEI), on non-heart-beating donor grafts was evaluated using an orthotopic liver transplantation model in rats. METHODS Type 3 PDEI or normal saline (control group) was given(More)