Takashi Nicholas Maeda

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PURPOSE The aim of the study was to analyze the methylation status of the promoter regions of p15 and p16 and to assess the prognostic significance of promoter hypermethylation in diffuse large B-cell lymphoma (DLBCL). EXPERIMENTAL DESIGN DLBCL was diagnosed by morphology and immunohistochemical analysis according to the World Health Organization (WHO)(More)
Physical inactivity is a risk factor for the development of non-alcoholic fatty liver disease (NAFLD). “Hybrid training”, a training that involves both voluntary and electrical muscle contractions, causes beneficial alterations in muscles even after short durations of exercise. The aim of this study was to investigate the therapeutic efficacy of hybrid(More)
AIMS : Familial accumulation of primary biliary cirrhosis (PBC) has been documented. To examine the importance of genetic factors, we carried out family study of the disease with a particular focus on the reactivity profiles of anti-mitochondrial antibodies (AMA). PATIENTS AND METHODS : Eighty-five patients with PBC that we experienced in the period of(More)
Five-dimensional N = 1 supersymmetric Yang-Mills theories are investigated from the viewpoint of random plane partitions. It is shown that random plane partitions are factorizable as q-deformed random partitions so that they admit the interpretations as five-dimensional Yang-Mills and as topological string amplitudes. In particular, they lead to the exact(More)
We study Kähler gravity on local SU(N) geometry and describe precise correspondence with certain supersymmetric gauge theories and random plane partitions. The local geometry is discretized, via the geometric quantization, to a foam of an infinite number of gravitational quanta. We count these quanta in a relative manner by measuring a deviation of the(More)
Boundary interactions of closed-string with open-strings are examined intended to provide a constructive formulation of boundary string field theory. As an illustration, we consider the BPS D-brane of the type II superstring in a constant NS-NS two-form background, and study the boundary interaction with arbitrary configurations of gauge field on the brane.(More)
OBJECTIVE The benefits of 5-year tamoxifen administration for patients with estrogen receptor-positive breast cancer undoubtedly outweigh the risk of any adverse effects. Massive hepatic steatosis is an example of its side effects. Here we show risk factors for the development of massive hepatic steatosis and describe a representative clinical course of(More)
Increased subepithelial deposition of extracellular matrix proteins is a key feature in bronchial asthma. Matrix metalloproteinase-9 (MMP-9) is a proteolytic enzyme that degrades the extracellular matrix. Tenascin is an extracellular matrix glycoprotein that is abundant in thickened asthmatic subbasement membrane. The expression of MMP-9 and tenascin(More)
Serum antibody against carbonic anhydrase (CA) II has been described as a serological marker for distinguishing autoimmune cholangitis (AIC) from primary biliary cirrhosis (PBC). To validate this finding in a Japanese population, we evaluated sera from patients with PBC and AIC for antibody to human CA II. An enzyme-linked immunosorbent assay was employed(More)
OBJECTIVE To assess an exercise program that uses electrically stimulated antagonists to resist agonist muscle contractions. DESIGN In 1 limb, electrically stimulated antagonists resisted elbow flexion and extension. In the other, stimulation occurred without volitional muscle contraction. SETTING A biomechanics laboratory in Japan. PARTICIPANTS(More)